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Literature DB >> 47710

Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.

Abstract

An analysis of the inherited pattern of C-band heterochromatin has been made in five pedigrees containing a total of 33 offspring that were available for analysis. The majority of variants were found to be inherited; however, at least seven of the 99 variants were not present in either parent, and an additional seven differed from the parental variant by either a morphological change or the appearance of mosaicism. It is believed that the polymorphism of human constitutive heterochromatin arises from a mismatching of the repetitive DNA sequences contained in these regions with subsequent unequal crossing over. Further, the observed mosaic patterns provide suggestive evidence that such an event occurs in somatic cells as well as during meiosis.

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Year: 1975 PMID： 47710 PMCID： PMC1762738

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

30 in total

1. Genetic analysis based on mitotic recombination.

Authors: G PONTECORVO; E KAFER
Journal: Adv Genet Date: 1958 Impact factor: 1.944

Review 2. Antibody variability. Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability.

Authors: O Smithies
Journal: Science Date: 1967-07-21 Impact factor: 47.728

Polymporphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over.

1. Genetic analysis based on mitotic recombination.

Review 2. Antibody variability. Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability.

3. The nature and inheritance of an elongated secondary constriction on chromosome 9 of man.

4. New selective Giemsa technique for human chromosomes, Cd staining.

5. Letter: Sequential G and C chromosome banding.

6. An analysis of the technical variables in the production of C bands.

7. [Polymorphism of human constitutive heterochromatin in metaphase chromosome A1].

8. A simple method to sequentially reveal Q-and C-bands on the same metaphase chromosomes.

9. CYTOLOGICAL EVIDENCE FOR CROSSING-OVER IN VITRO IN HUMAN LYMPHOID CELLS.

10. Human chromosomes in 18 man-mouse somatic hybrid cell lines analysed by quinacrine fluorescence.

Review 1. Twinning and mitotic crossing-over: some possibilities and their implications.

2. Inheritance of chromosome heteromorphisms analyzed by high-resolution bivariate flow karyotyping.

3. Morphologic variability of human chromosomes: polymorphism of constitutive heterochromatin.

4. Origin of the extra chromosome no. 21 in Down's syndrome.

5. Pitfalls in the use of chromosome variants for paternity dispute cases.

6. Classification of qh regions in human chromosomes 1, 9, and 16 by C-banding.

7. LBA technique in the detection of chromosome variants. II. Chromosomes except for those with Q variants.

Review 8. Pericentric inversions. Problems and significance for clinical genetics.

9. Variation in human acrocentric chromosomes with acridine orange reverse banding.

10. Polymorphism of human chromosomes 1, 9, 16, Y: variations, segregation and mosaicism.