Literature DB >> 6441954

Pharmacogenetics of phenylethylamine: determination of heritability and genetic transmission of locomotor effects in recombinant inbred strains of mice.

D V Jeste, D M Stoff, R Rawlings, R J Wyatt.   

Abstract

beta-Phenylethylamine (PEA) is an amphetamine-like compound that is postulated to be a possible endogenous psychotogen. We studied locomotor response to PEA in two inbred progenitor strains of mice (C57BL/6 By and BALB/c By), their reciprocal F1 hybrids (B6CF1 and CB6F1), and seven recombinant inbred strains (CXBD, CXBE, CXBG, CXBH, CXBI, CXGJ, and CXBK). Univariate and multivariate statistical analyses were done. Heritability of the response to PEA was 82%. The strain distribution pattern was suggestive of the inheritance of the trait through a single major gene locus.

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Year:  1984        PMID： 6441954     DOI： 10.1007/bf00431462

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  14 in total

1.  Enzymatic isotopic assay for and presence of beta-phenylethylamine in brain.

Authors:  J M Saavedra
Journal:  J Neurochem       Date:  1974-02       Impact factor: 5.372

2.  Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes.

Authors:  D W Bailey
Journal:  Transplantation       Date:  1971-03       Impact factor: 4.939

3.  Increased dopamine and norepinephrine concentrations in primate CSF following amphetamine and phenylethylamine administration.

Authors:  M J Perlow; C C Chiueh; C R Lake; R J Wyatt
Journal:  Brain Res       Date:  1980-03-31       Impact factor: 3.252

4.  Does phenylethylamine cause schizophrenia?

Authors:  M Sandler; G P Reynolds
Journal:  Lancet       Date:  1976-01-10       Impact factor: 79.321

5.  beta-Phenylethylamine reversal of chlorpromazine-induced activation of striatal tyrosine hydroxylase and catalepsy.

Authors:  D M Stoff; K Gale
Journal:  Brain Res       Date:  1981-05-04       Impact factor: 3.252

6.  Genetic control of dopamine and serotonin receptors in brain regions of inbred mice.

Authors:  R E Boehme; R D Ciaranello
Journal:  Brain Res       Date:  1983-04-25       Impact factor: 3.252

7.  Genetic analysis of the behavioral response to d-amphetamine in mice.

Authors:  B Moisset
Journal:  Psychopharmacology (Berl)       Date:  1977-08-16       Impact factor: 4.530

8.  Cross-cultural study of a biochemical abnormality in paranoid schizophrenia.

Authors:  D V Jeste; D R Doongaji; D Panjwani; M Datta; S G Potkin; F Karoum; S Thatte; A S Sheth; J S Apte; R J Wyatt
Journal:  Psychiatry Res       Date:  1981-12       Impact factor: 3.222

9.  Mesolimbicocortical dopamine terminal fields are necessary for normal locomotor and investigatory exploration in rats.

Authors:  J S Fink; G P Smith
Journal:  Brain Res       Date:  1980-10-20       Impact factor: 3.252

10.  Phenylethylamine in paranoid chronic schizophrenia.

Authors:  S G Potkin; F Karoum; L W Chuang; H E Cannon-Spoor; I Phillips; R J Wyatt
Journal:  Science       Date:  1979-10-26       Impact factor: 47.728
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  2 in total

1.  Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel.

Authors:  Lauren S Bailey; Jared R Bagley; Rainy Dodd; Ashley Olson; Mikayla Bolduc; Vivek M Philip; Laura G Reinholdt; Stacey J Sukoff Rizzo; Lisa Tarantino; Leona Gagnon; Elissa J Chesler; James David Jentsch
Journal:  Genes Brain Behav       Date:  2021-10-21       Impact factor: 3.708

Review 2.  Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice.

Authors:  J K Belknap; P Metten; M L Helms; L A O'Toole; S Angeli-Gade; J C Crabbe; T J Phillips
Journal:  Behav Genet       Date:  1993-03       Impact factor: 2.805
  2 in total

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