Literature DB >> 6439824

Amyotrophic lateral sclerosis: a double-blind crossover trial of thyrotropin-releasing hormone.

K Imoto, K Saida, K Iwamura, T Saida, H Nishitani.   

Abstract

A double-blind crossover trial was conducted of thyrotropin releasing hormone treatment in six patients with amyotrophic lateral sclerosis. Patients received 4 mg of thyrotropin releasing hormone intramuscularly daily during the two-week treatment period. Although three patients reported subjective improvement, objective evaluation failed to demonstrate therapeutic effectiveness of thyrotropin releasing hormone in this dosage.

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Year:  1984        PMID： 6439824      PMCID： PMC1028142          DOI： 10.1136/jnnp.47.12.1332

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  6 in total

1.  Stimulant action of thyrotropin releasing hormone on cat spinal cord.

Authors:  B R Cooper; C E Boyer
Journal:  Neuropharmacology       Date:  1978-02       Impact factor: 5.250

2.  Distribution of thyrotropin-releasing hormone (TRH) in the central nervous system as revealed with immunohistochemistry.

Authors:  T Hökfelt; K Fuxe; O Johansson; S Jeffcoate; N White
Journal:  Eur J Pharmacol       Date:  1975-12       Impact factor: 4.432

3.  Controlled trial of thyrotropin releasing hormone tartrate in ataxia of spinocerebellar degenerations.

Authors:  I Sobue; T Takayanagi; T Nakanishi; T Tsubaki; M Uono; M Kinoshita; A Igata; M Miyazaki; M Yoshida; K Ando
Journal:  J Neurol Sci       Date:  1983-10       Impact factor: 3.181

4.  Thyrotropin-releasing hormone (TRH) in rat spinal cord.

Authors:  F C Kardon; A Winokur; R D Utiger
Journal:  Brain Res       Date:  1977-02-25       Impact factor: 3.252

5.  Effect on weakness and spasticity in amyotrophic lateral sclerosis of thyrotropin-releasing hormone.

Authors:  W K Engel; T Siddique; J T Nicoloff
Journal:  Lancet       Date:  1983-07-09       Impact factor: 79.321

6.  Thyrotropin-releasing hormone: regional distribution in rat brain.

Authors:  A Winokur; R D Utiger
Journal:  Science       Date:  1974-07-19       Impact factor: 47.728
  6 in total
  5 in total

1.  Amyotrophic Lateral Sclerosis.

Authors: 
Journal:  Curr Treat Options Neurol       Date:  2000-01       Impact factor: 3.598

2.  Low doses of TRH in amyotrophic lateral sclerosis and in other neurological diseases.

Authors:  S Congia; S Tronci; M Ledda; A Porcella; G Coppola
Journal:  Ital J Neurol Sci       Date:  1991-04

3.  Subacute administration of a TRH analogue (RX77368) in motorneuron disease: an open study.

Authors:  H Modarres-Sadeghi; H Rogers; J Emami; R J Guiloff
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-09       Impact factor: 10.154

4.  Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease.

Authors:  R J Guiloff; D J Eckland; C Demaine; R C Hoare; K D MacRae; S L Lightman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-10       Impact factor: 10.154

5.  Single-compartment model analysis of thyrotropin-releasing hormone kinetics in hyper- and hypothyroid patients. Kinetic studies using a combined system of RIA and FPLC.

Authors:  L Duntas; F S Keck; J Rosenthal; C Wolf; U Loos; E F Pfeiffer
Journal:  Klin Wochenschr       Date:  1990-10-17
  5 in total

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