Literature DB >> 6438526

Expression of active human factor VIII from recombinant DNA clones.

W I Wood, D J Capon, C C Simonsen, D L Eaton, J Gitschier, B Keyt, P H Seeburg, D H Smith, P Hollingshead, K L Wion, E Delwart, E G Tuddenham, G A Vehar, R M Lawn.   

Abstract

DNA clones encoding the complete 2,351 amino acid sequence for human factor VIII have been isolated and used to produce biologically active factor VIII in cultured mammalian cells. The recombinant protein corrects the clotting time of plasma from haemophiliacs and has many of the biochemical and immunological characteristics of serum-derived factor VIII.

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Year:  1984        PMID： 6438526     DOI： 10.1038/312330a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  104 in total

1.  Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons.

Authors:  R S Bhatt; T Tomoda; Y Fang; M E Hatten
Journal:  Genes Dev       Date:  2000-09-01       Impact factor: 11.361

2.  First determination of the secondary structure of purified factor VIII light chain.

Authors:  N Bihoreau; M P Fontaine-Aupart; A Lehegarat; M Desmadril; J M Yon
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

3.  Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.

Authors:  P J Godowski; D W Leung; L R Meacham; J P Galgani; R Hellmiss; R Keret; P S Rotwein; J S Parks; Z Laron; W I Wood
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

4.  pH-dependent association of factor VIII chains: enhancement of affinity at physiological pH by Cu2+.

Authors:  Hironao Wakabayashi; Qian Zhou; Keiji Nogami; Charles Ansong; Fatbardha Varfaj; Stephen Miles; Philip J Fay
Journal:  Biochim Biophys Acta       Date:  2006-04-22

5.  Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

Authors:  D Pennica; J S Hayflick; T S Bringman; M A Palladino; D V Goeddel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

6.  Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.

Authors:  J P Adelman; A J Mason; J S Hayflick; P H Seeburg
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

7.  Inversions in the factor VIII gene: improvement of carrier detection and prenatal diagnosis in Dutch haemophilia A families.

Authors:  P P Deutz-Terlouw; M Losekoot; R Olmer; W C Pieneman; S de Vries-v d Weerd; E Briët; E Bakker
Journal:  J Med Genet       Date:  1995-04       Impact factor: 6.318

8.  Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.

Authors:  Zhuo Liu; Lin Lin; Cai Yuan; Gerry A F Nicolaes; Liqing Chen; Edward J Meehan; Bruce Furie; Barbara Furie; Mingdong Huang
Journal:  J Biol Chem       Date:  2010-01-20       Impact factor: 5.157

9.  Detection of mutations in ectopic factor VIII transcripts from nine haemophilia A patients and the correlation with phenotype.

Authors:  S I Bidichandani; W G Lanyon; C R Shiach; G D Lowe; J M Connor
Journal:  Hum Genet       Date:  1995-05       Impact factor: 4.132

10.  Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression.

Authors:  J McLean; K Wion; D Drayna; C Fielding; R Lawn
Journal:  Nucleic Acids Res       Date:  1986-12-09       Impact factor: 16.971
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