Literature DB >> 2867548

Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.

J P Adelman, A J Mason, J S Hayflick, P H Seeburg.   

Abstract

Cloned cDNAs encoding the precursor protein for gonadotropin-releasing hormone (Gn-RH) and prolactin release-inhibiting factor (PIF) were isolated from libraries derived from human and rat hypothalamic mRNA. Nucleotide sequence analyses predict precursor proteins of 92 amino acids for both species and show identity between the human placental and human hypothalamic precursor proteins. Whereas the Gn-RH peptide structure is completely conserved in human and rat, the PIF domain of the precursor displays 70% interspecies homology. Genomic analyses revealed the presence of a single Gn-RH-PIF gene in human and rat containing sequences corresponding to the cDNA distributed across four exons.

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Year:  1986        PMID： 2867548      PMCID： PMC322815          DOI： 10.1073/pnas.83.1.179

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Efficeint transcription of RNA into DNA by avian sarcoma virus polymerase.

Authors:  J M Taylor; R Illmensee; J Summers
Journal:  Biochim Biophys Acta       Date:  1976-09-06

2.  RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.

Authors:  H Lehrach; D Diamond; J M Wozney; H Boedtker
Journal:  Biochemistry       Date:  1977-10-18       Impact factor: 3.162

3.  Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors:  W D Benton; R W Davis
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

4.  3' non-coding region sequences in eukaryotic messenger RNA.

Authors:  N J Proudfoot; G G Brownlee
Journal:  Nature       Date:  1976-09-16       Impact factor: 49.962

5.  Isolation and characterization of chicken hypothalamic luteinizing hormone-releasing hormone.

Authors:  K Miyamoto; Y Hasegawa; T Minegishi; M Nomura; Y Takahashi; M Igarashi; K Kangawa; H Matsuo
Journal:  Biochem Biophys Res Commun       Date:  1982-08       Impact factor: 3.575

6.  Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.

Authors:  J Garnier; D J Osguthorpe; B Robson
Journal:  J Mol Biol       Date:  1978-03-25       Impact factor: 5.469

7.  Isolation of high-molecular-weight DNA from mammalian cells.

Authors:  M Gross-Bellard; P Oudet; P Chambon
Journal:  Eur J Biochem       Date:  1973-07-02

8.  The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors:  R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

9.  Gonadotropin-releasing hormone in milk.

Authors:  T Baram; Y Koch; E Hazum; M Fridkin
Journal:  Science       Date:  1977-10-21       Impact factor: 47.728

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
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  43 in total

1.  Characterization of a cDNA encoding a novel avian hypothalamic neuropeptide exerting an inhibitory effect on gonadotropin release.

Authors:  H Satake; M Hisada; T Kawada; H Minakata; K Ukena; K Tsutsui
Journal:  Biochem J       Date:  2001-03-01       Impact factor: 3.857

2.  Gonadotropin-releasing hormone messenger ribonucleic acid and protein expression in Vero cells.

Authors:  H Y Huang; F Raga; J S Kruessel; Y Wen; Y K Soong; M L Polan
Journal:  J Assist Reprod Genet       Date:  2001-05       Impact factor: 3.412

3.  Placental progonadotropin-releasing hormone (pro-GnRH) in the rhesus monkey.

Authors:  T M Duello; T A Boyle
Journal:  Endocrine       Date:  1997-02       Impact factor: 3.633

Review 4.  Gonadotropin-releasing hormone (GnRH): from fish to mammalian brains.

Authors:  Gustavo M Somoza; Leandro A Miranda; Pablo Strobl-Mazzulla; Leonardo Gastón Guilgur
Journal:  Cell Mol Neurobiol       Date:  2002-12       Impact factor: 5.046

5.  Mast cells in the rat brain synthesize gonadotropin-releasing hormone.

Authors:  Mona H Khalil; Ann-Judith Silverman; Rae Silver
Journal:  J Neurobiol       Date:  2003-08

6.  Gene expression of gonadotropin-releasing hormone and its receptor in rat pancreatic cancer cell lines.

Authors:  L Wang; L P Xie; R Q Zhang
Journal:  Endocrine       Date:  2001-04       Impact factor: 3.633

7.  Immunocytochemical localization of the gonadotropin-releasing hormone-associated peptide portion of the LHRH precursor in the hypothalamus and extrahypothalamic regions of the rat central nervous system.

Authors:  I Merchenthaler; M D Culler; P Petrusz; B Flerkó; A Negro-Vilar
Journal:  Cell Tissue Res       Date:  1989-01       Impact factor: 5.249

Review 8.  Control of luteinizing hormone-releasing hormone pulse generation in nonhuman primates.

Authors:  E Terasawa
Journal:  Cell Mol Neurobiol       Date:  1995-02       Impact factor: 5.046

Review 9.  Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells.

Authors:  M E Wierman; J M Bruder; J K Kepa
Journal:  Cell Mol Neurobiol       Date:  1995-02       Impact factor: 5.046

10.  Substance P-, F8Famide-, and A18Famide-like immunoreactivity in the nervus terminalis and retina of the goldfish Carassius auratus.

Authors:  A L Kyle; B G Luo; T H Magnus; W K Stell
Journal:  Cell Tissue Res       Date:  1995-06       Impact factor: 5.249
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