Literature DB >> 6422553

Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity.

K Ramasharma, M R Sairam, N G Seidah, M Chrétien, P Manjunath, P W Schiller, D Yamashiro, C H Li.   

Abstract

A basic peptide isolated from pooled human seminal plasma exhibited inhibin-like activity by suppressing pituitary follicle-stimulating hormone secretion in vitro and in vivo. The peptide has been characterized and sequenced, and a 31-amino-acid synthetic replicate showed full biological activity in vitro.

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Year:  1984        PMID： 6422553     DOI： 10.1126/science.6422553

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Synthetic peptide with inhibin-like activity preferentially inhibits follitropin secretion in comparison with lutropin-releasing hormone antagonists.

Authors:  M R Sairam; K Ramasharma; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

2.  Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes.

Authors:  K Ramasharma; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

3.  Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid.

Authors:  N Ling; S Y Ying; N Ueno; F Esch; L Denoroy; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

4.  Synthetic human seminal alpha-inhibin-92 selectively suppresses follicle-stimulating hormone release in vivo.

Authors:  W H Yu; S M McCann; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

5.  Synthesis and biological activity of human inhibin-like peptide-(1-31).

Authors:  D Yamashiro; C H Li; K Ramasharma; M R Sairam
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

6.  Human seminal alpha-inhibins: detection in human pituitary, hypothalamus, and serum by immunoreactivity.

Authors:  K Ramasharma; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

7.  Human seminal alpha inhibins: isolation, characterization, and structure.

Authors:  C H Li; R G Hammonds; K Ramasharma; D Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205
  7 in total

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