Literature DB >> 3124100

Synthetic human seminal alpha-inhibin-92 selectively suppresses follicle-stimulating hormone release in vivo.

W H Yu1, S M McCann, C H Li.   

Abstract

A 92-amino acid polypeptide, alpha-inhibin-92 (alpha-IB-92), has been isolated and characterized from human seminal plasma and found to be active in suppressing follicle-stimulating hormone (FSH) release in vitro. In the present in vivo study, intravenous injection of synthetic alpha-IB-92 (4 and 20 micrograms) significantly suppressed FSH release (P less than 0.001), whereas this peptide had no effect on luteinizing hormone (LH) release in 1-day orchidectomized male rats. In contrast, third ventricular injection of alpha-IB-92 (0.02, 0.4, 4, or 20 micrograms) had no effect on FSH and LH release in 1- or 2-day orchidectomized rats. These results indicate that alpha-IB-92 exerts a FSH suppressing activity by direct action on the pituitary gland.

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Year:  1988        PMID： 3124100      PMCID： PMC279530          DOI： 10.1073/pnas.85.1.289

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

Review 1.  Inhibin: from concept to reality.

Authors:  P Franchimont; J Verstraelen-Proyard; M T Hazee-Hagelstein; C Renard; A Demoulin; J P Bourguignon; J Hustin
Journal:  Vitam Horm       Date:  1979       Impact factor: 3.421

2.  Isolation of a 31 kDa form of inhibin from bovine follicular fluid.

Authors:  D M Robertson; F L de Vos; L M Foulds; R I McLachlan; H G Burger; F J Morgan; M T Hearn; D M de Kretser
Journal:  Mol Cell Endocrinol       Date:  1986-03       Impact factor: 4.102

3.  Chemical synthesis of alpha-inhibin-92 by the thiocarboxyl segment coupling method.

Authors:  J Blake; D Yamashiro; K Ramasharma; C H Li
Journal:  Int J Pept Protein Res       Date:  1986-11

4.  Hormonal regulation of inhibin production by cultured Sertoli cells.

Authors:  T A Bicsak; W Vale; J Vaughan; E M Tucker; S Cappel; A J Hsueh
Journal:  Mol Cell Endocrinol       Date:  1987-02       Impact factor: 4.102

5.  A rapid and simple procedure for chronic cannulation of the rat jugular vein.

Authors:  P G Harms; S R Ojeda
Journal:  J Appl Physiol       Date:  1974-03       Impact factor: 3.531

6.  Radioimmunoassay for rat luteinizing hormone with antiovine LH serum and ovine LH-131-I.

Authors:  G D Niswender; A R Midgley; S E Monroe; L E Reichert
Journal:  Proc Soc Exp Biol Med       Date:  1968-07

7.  Isolation of porcine follicular fluid inhibin of 32K daltons.

Authors:  K Miyamoto; Y Hasegawa; M Fukuda; M Nomura; M Igarashi; K Kangawa; H Matsuo
Journal:  Biochem Biophys Res Commun       Date:  1985-06-14       Impact factor: 3.575

8.  Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity.

Authors:  K Ramasharma; M R Sairam; N G Seidah; M Chrétien; P Manjunath; P W Schiller; D Yamashiro; C H Li
Journal:  Science       Date:  1984-03-16       Impact factor: 47.728

9.  Secretion of an FSH-inhibiting factor by cultured Sertoli cells.

Authors:  A Steinberger; E Steinberger
Journal:  Endocrinology       Date:  1976-09       Impact factor: 4.736

10.  Inhibin: measurement and role in the immature female rat.

Authors:  C Rivier; W Vale
Journal:  Endocrinology       Date:  1987-04       Impact factor: 4.736
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