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Literature DB >> 6421427

Reversal by verapamil of defect in sodium transport in leucocytes in essential hypertension.

H H Gray, L Poston, P J Hilton, S J Smith, N D Markandu, G A MacGregor.

Abstract

The effect of treatment with verapamil on cell sodium transport was studied in the leucocytes of patients with essential hypertension. Previously described abnormalities of sodium efflux rate constant and intracellular sodium content were confirmed, the component of the sodium efflux rate constant sensitive to ouabain being lower and the intracellular sodium content higher in the patients compared with controls. Verapamil reversed these abnormalities and reduced blood pressure.

Entities: Chemical Disease Species

Mesh：

Substances：
Sodium
Verapamil

Year: 1984 PMID： 6421427 PMCID： PMC1444437 DOI： 10.1136/bmj.288.6418.673

Source DB: PubMed Journal: Br Med J (Clin Res Ed) ISSN： 0267-0623

10 in total

1. The sodium pump.

Authors: I M Glynn; S J Karlish
Journal: Annu Rev Physiol Date: 1975 Impact factor: 19.318

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. Sodium and potassium flux rates in normal human leucocytes in an artificial extracellular fluid.

Authors: P J Hilton; J Patrick
Journal: Clin Sci Date: 1973-05 Impact factor: 6.124

4. The control by internal calcium of membrane permeability to sodium and potassium.

Authors: P J Romero; R Whittam
Journal: J Physiol Date: 1971-05 Impact factor: 5.182

Review 5. Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.

Authors: M P Blaustein
Journal: Am J Physiol Date: 1977-05

6. Leucocyte membrane sodium transport in normotensive populations: dissociation of abnormalities of sodium efflux from raised blood-pressure.

Authors: A M Heagerty; M Milner; R F Bing; H Thurston; J D Swales
Journal: Lancet Date: 1982-10-23 Impact factor: 79.321

3 in total

Reversal by verapamil of defect in sodium transport in leucocytes in essential hypertension.

1. The sodium pump.

2. Protein measurement with the Folin phenol reagent.

3. Sodium and potassium flux rates in normal human leucocytes in an artificial extracellular fluid.

4. The control by internal calcium of membrane permeability to sodium and potassium.

Review 5. Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.

6. Leucocyte membrane sodium transport in normotensive populations: dissociation of abnormalities of sodium efflux from raised blood-pressure.

7. The effect of antihypertensive therapy on abnormal leucocyte sodium transport in essential hypertension.

8. The effect of the internal sodium concentration on calcium fluxes in isolated guinea-pig auricles.

9. Abnormal leucocyte composition and sodium transport in essential hypertension.

10. Evidence for a circulating sodium transport inhibitor in essential hypertension.

1. Reversible inhibition of leucocyte sodium pumps by a circulating serum factor in essential hypertension.

Review 2. Calcium channel blocking agents and the heart.

3. Noradrenaline: a circulating inhibitor of sodium transport.