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Literature DB >> 6420706

Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus.

A C Hayday, S D Gillies, H Saito, C Wood, K Wiman, W S Hayward, S Tonegawa.

Abstract

A tissue-specific transcriptional enhancer element that is associated with the human immunoglobulin heavy-chain locus is defined. In a non-Hodgkin's lymphoma that contains a translocated c-myc gene this enhancer is retained on the 14q+ chromosome and occurs within sequences shown to activate previously cryptic promoters of the c-myc gene.

Entities: Disease Gene Species

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Year: 1984 PMID： 6420706 DOI： 10.1038/307334a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

80 in total

1. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability.

Authors: A Hellman; A Rahat; S W Scherer; A Darvasi; L C Tsui; B Kerem
Journal: Mol Cell Biol Date: 2000-06 Impact factor: 4.272

2. Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU.

Authors: N E Wittekindt; K Hörtnagel; C Geltinger; A Polack
Journal: Nucleic Acids Res Date: 2000-02-01 Impact factor: 16.971

9. NF-kappa B sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma.

Authors: L Ji; M Arcinas; L M Boxer
Journal: Mol Cell Biol Date: 1994-12 Impact factor: 4.272

10. Translocation and rearrangement of c-myc into immunoglobulin alpha heavy chain locus in primary cells from acute lymphocytic leukemia.

Authors: C Peschle; F Mavilio; N M Sposi; A Giampaolo; A Caré; L Bottero; M Bruno; G Mastroberardino; R Gastaldi; M G Testa
Journal: Proc Natl Acad Sci U S A Date: 1984-09 Impact factor: 11.205

Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus.

1. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability.

2. Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU.

3. Stimulation of pancreatic islet beta-cell replication by oncogenes.

4. Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity.

5. A 5'-truncated c-myc gene variant not associated with a risk of cancer.

6. The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.

Review 7. Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.

8. Accurate and efficient transcription of human c-myc genes injected into Xenopus laevis oocytes.

9. NF-kappa B sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma.

10. Translocation and rearrangement of c-myc into immunoglobulin alpha heavy chain locus in primary cells from acute lymphocytic leukemia.