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Literature DB >> 15743832

The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.

Monica Cardone¹, Ayten Kandilci, Cintia Carella, Jonas A Nilsson, Jennifer A Brennan, Sema Sirma, Ugur Ozbek, Kelli Boyd, John L Cleveland, Gerard C Grosveld.

Abstract

The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 15743832 PMCID： PMC1061619 DOI： 10.1128/MCB.25.6.2395-2405.2005

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

48 in total

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23 in total

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Review 4. The ETS family of oncogenic transcription factors in solid tumours.

Authors: Gina M Sizemore; Jason R Pitarresi; Subhasree Balakrishnan; Michael C Ostrowski
Journal: Nat Rev Cancer Date: 2017-04-28 Impact factor: 60.716

5. MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice.

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