Literature DB >> 6420386

The myxopyronins, new inhibitors of bacterial RNA synthesis from Myxococcus fulvus (Myxobacterales).

H Irschik, K Gerth, G Höfle, W Kohl, H Reichenbach.   

Abstract

From the culture supernatant of the myxobacterium, Myxococcus fulvus strain Mx f50, an antibiotic activity was isolated which blocked growth of many Gram-positive and several Gram-negative bacteria, but not of yeasts and fungi. The activity consisted of two closely related compounds, myxopyronins A and B. The myxopyronins appear to be new antibiotics, and seem to specifically inhibit bacterial RNA polymerase.

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Year:  1983        PMID： 6420386     DOI： 10.7164/antibiotics.36.1651

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  24 in total

1.  Influence of DNA template choice on transcription and inhibition of Escherichia coli RNA polymerase.

Authors:  Joerg Haupenthal; Kristina Hüsecken; Matthias Negri; Christine K Maurer; Rolf W Hartmann
Journal:  Antimicrob Agents Chemother       Date:  2012-06-04       Impact factor: 5.191

Review 2.  Bacterial Transcription as a Target for Antibacterial Drug Development.

Authors:  Cong Ma; Xiao Yang; Peter J Lewis
Journal:  Microbiol Mol Biol Rev       Date:  2016-01-13       Impact factor: 11.056

3.  Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase.

Authors:  Katherine Mariner; Martin McPhillie; Rachel Trowbridge; Catriona Smith; Alex J O'Neill; Colin W G Fishwick; Ian Chopra
Journal:  Antimicrob Agents Chemother       Date:  2011-02-14       Impact factor: 5.191

4.  Novel hybrid-type antimicrobial agents targeting the switch region of bacterial RNA polymerase.

Authors:  Fumika Yakushiji; Yuko Miyamoto; Yuki Kunoh; Reiko Okamoto; Hidemasa Nakaminami; Yuri Yamazaki; Norihisa Noguchi; Yoshio Hayashi
Journal:  ACS Med Chem Lett       Date:  2013-01-11       Impact factor: 4.345

5.  Germicidins H-J from Streptomyces sp. CB00361.

Authors:  Ming Ma; Mostafa E Rateb; Dong Yang; Jeffrey D Rudolf; Xiangcheng Zhu; Yong Huang; Li-Xing Zhao; Yi Jiang; Yanwen Duan; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2016-08-10       Impact factor: 2.649

6.  Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

Authors:  Sonia I Maffioli; Yu Zhang; David Degen; Thomas Carzaniga; Giancarlo Del Gatto; Stefania Serina; Paolo Monciardini; Carlo Mazzetti; Paola Guglierame; Gianpaolo Candiani; Alina Iulia Chiriac; Giuseppe Facchetti; Petra Kaltofen; Hans-Georg Sahl; Gianni Dehò; Stefano Donadio; Richard H Ebright
Journal:  Cell       Date:  2017-06-15       Impact factor: 41.582

7.  Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo.

Authors:  Fredericke Kock; Matthias Hauptmann; Anke Osterloh; Till F Schäberle; Sven Poppert; Hagen Frickmann; Klaus-Dieter Menzel; Gundela Peschel; Kenneth Pfarr; Andrea Schiefer; Gabriele M König; Achim Hoerauf; Bernhard Fleischer; Christian Keller
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

8.  Tie me up, tie me down: inhibiting RNA polymerase.

Authors:  Rui Sousa
Journal:  Cell       Date:  2008-10-17       Impact factor: 41.582

9.  Frequency, spectrum, and nonzero fitness costs of resistance to myxopyronin in Staphylococcus aureus.

Authors:  Aashish Srivastava; David Degen; Yon W Ebright; Richard H Ebright
Journal:  Antimicrob Agents Chemother       Date:  2012-09-24       Impact factor: 5.191

10.  Transcription inactivation through local refolding of the RNA polymerase structure.

Authors:  Georgiy A Belogurov; Marina N Vassylyeva; Anastasiya Sevostyanova; James R Appleman; Alan X Xiang; Ricardo Lira; Stephen E Webber; Sergiy Klyuyev; Evgeny Nudler; Irina Artsimovitch; Dmitry G Vassylyev
Journal:  Nature       Date:  2008-10-22       Impact factor: 49.962
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