Literature DB >> 18957193

Tie me up, tie me down: inhibiting RNA polymerase.

Rui Sousa1.   

Abstract

Mechanistic understanding of antibiotic action can yield crucial insights that aid in the design of new antibiotics. In this issue, Mukhopadhyay et al. (2008) uncover the mechanism by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region in RNA polymerase for inhibitor design.

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Year:  2008        PMID： 18957193      PMCID： PMC4443808          DOI： 10.1016/j.cell.2008.09.052

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  9 in total

1.  Architecture of RNA polymerase II and implications for the transcription mechanism.

Authors:  P Cramer; D A Bushnell; J Fu; A L Gnatt; B Maier-Davis; N E Thompson; R R Burgess; A M Edwards; P R David; R D Kornberg
Journal:  Science       Date:  2000-04-28       Impact factor: 47.728

2.  Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.

Authors:  A L Gnatt; P Cramer; J Fu; D A Bushnell; R D Kornberg
Journal:  Science       Date:  2001-04-19       Impact factor: 47.728

3.  The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin.

Authors:  Craig D Kaplan; Karl-Magnus Larsson; Roger D Kornberg
Journal:  Mol Cell       Date:  2008-06-06       Impact factor: 17.970

4.  Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation.

Authors:  Florian Brueckner; Patrick Cramer
Journal:  Nat Struct Mol Biol       Date:  2008-06-13       Impact factor: 15.369

5.  The myxopyronins, new inhibitors of bacterial RNA synthesis from Myxococcus fulvus (Myxobacterales).

Authors:  H Irschik; K Gerth; G Höfle; W Kohl; H Reichenbach
Journal:  J Antibiot (Tokyo)       Date:  1983-12       Impact factor: 2.649

6.  Structural mechanism for rifampicin inhibition of bacterial rna polymerase.

Authors:  E A Campbell; N Korzheva; A Mustaev; K Murakami; S Nair; A Goldfarb; S A Darst
Journal:  Cell       Date:  2001-03-23       Impact factor: 41.582

Review 7.  Bacterial RNA polymerase: a promising target for the discovery of new antimicrobial agents.

Authors:  Ian Chopra
Journal:  Curr Opin Investig Drugs       Date:  2007-08

8.  Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.

Authors:  Steven Tuske; Stefan G Sarafianos; Xinyue Wang; Brian Hudson; Elena Sineva; Jayanta Mukhopadhyay; Jens J Birktoft; Olivier Leroy; Sajida Ismail; Arthur D Clark; Chhaya Dharia; Andrew Napoli; Oleg Laptenko; Jookyung Lee; Sergei Borukhov; Richard H Ebright; Eddy Arnold
Journal:  Cell       Date:  2005-08-26       Impact factor: 41.582

9.  The RNA polymerase "switch region" is a target for inhibitors.

Authors:  Jayanta Mukhopadhyay; Kalyan Das; Sajida Ismail; David Koppstein; Minyoung Jang; Brian Hudson; Stefan Sarafianos; Steven Tuske; Jay Patel; Rolf Jansen; Herbert Irschik; Eddy Arnold; Richard H Ebright
Journal:  Cell       Date:  2008-10-17       Impact factor: 41.582
  9 in total
  2 in total

Review 1.  New target for inhibition of bacterial RNA polymerase: 'switch region'.

Authors:  Aashish Srivastava; Meliza Talaue; Shuang Liu; David Degen; Richard Y Ebright; Elena Sineva; Anirban Chakraborty; Sergey Y Druzhinin; Sujoy Chatterjee; Jayanta Mukhopadhyay; Yon W Ebright; Alex Zozula; Juan Shen; Sonali Sengupta; Rui Rong Niedfeldt; Cai Xin; Takushi Kaneko; Herbert Irschik; Rolf Jansen; Stefano Donadio; Nancy Connell; Richard H Ebright
Journal:  Curr Opin Microbiol       Date:  2011-08-19       Impact factor: 7.934

2.  Study of Functional and Allosteric Sites in Protein Superfamilies.

Authors:  D Suplatov; V Švedas
Journal:  Acta Naturae       Date:  2015 Oct-Dec       Impact factor: 1.845
  2 in total

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