| Literature DB >> 6413804 |
J A Lindsey, N Morisaki, J M Stitts, R A Zager, D G Cornwell.
Abstract
Cyclosporin-A (Cyc-A) stimulates prostanoid (PGI2) synthesis in confluent smooth muscle cells from guinea pig aorta through the release of endogenous fatty acid. Cyc-A, like other stimulatory agents for prostanoids, promotes smooth muscle cell proliferation and prostanoid synthesis in these proliferating cells. Indomethacin, a cyclooxygenase inhibitor, and exogenous arachidonic acid block the Cyc-A effect on cell proliferation.Entities:
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Year: 1983 PMID: 6413804 DOI: 10.1007/BF02535399
Source DB: PubMed Journal: Lipids ISSN: 0024-4201 Impact factor: 1.880