Literature DB >> 877555

Fatty acids and their prostaglandin derivatives: inhibitors of proliferation in aortic smooth muscle cells.

J J Huttner, E T Gwebu, R V Panganamala, G E Milo, D C Cornwell, H M Sharma, J C Geer.   

Abstract

Prostaglandins are synthesized from eicosa-8,11,14-trienoic acid and eicosa-5,8,11-14-tetraenoic acid by smooth muscle cell cultures from guinea pig aorta. Production is inhibited by indomethacin. The precursor fatty acids and their prostaglandin derivatives inhibit proliferation of the cell cultures. The relative availability of fatty acids for prostaglandin biosynthesis may represent a control mechanism for cell proliferation.

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Year:  1977        PMID： 877555     DOI： 10.1126/science.877555

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  29 in total

1.  Suppression of growth in a leukemic T cell line by n-3 and n-6 polyunsaturated fatty acids.

Authors:  S C Chow; L Sisfontes; I Björkhem; M Jondal
Journal:  Lipids       Date:  1989-08       Impact factor: 1.880

2.  Effects of authentic and VLDL hydrolysis-derived fatty acids on vascular smooth muscle cell growth.

Authors:  I Gouni-Berthold; H K Berthold; C Seul; Y Ko; H Vetter; A Sachinidis
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

3.  Fatty acids and the selective alteration of in vitro proliferation in human fibroblast and guinea-pig smooth-muscle cells.

Authors:  J J Huttner; G E Milo; R V Panganamala; D G Cornwell
Journal:  In Vitro       Date:  1978-10

4.  Eicosapentaenoic acid and docosahexaenoic acid selectively attenuate U46619-induced smooth muscle cell proliferation.

Authors:  R Pakala; R Pakala; C Benedict
Journal:  Lipids       Date:  1999-09       Impact factor: 1.880

5.  Fatty acid metabolism and cell proliferation. V. Evaluation of pathways for the generation of lipid peroxides.

Authors:  N Morisaki; J A Lindsey; J M Stitts; H Zhang; D G Cornwell
Journal:  Lipids       Date:  1984-06       Impact factor: 1.880

6.  Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression.

Authors:  T S Brannon; A J North; L B Wells; P W Shaul
Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808

7.  Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat.

Authors:  J Y Jeremy; C S Thompson; D P Mikhailidis
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

8.  Increased saturated phospholipid in cultured cells grown with linoleic acid.

Authors:  F B Smith; Y Kikkawa; C A Diglio; R C Dalen
Journal:  In Vitro       Date:  1982-04

9.  Fatty acid metabolism and cell proliferation: IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporin-A.

Authors:  J A Lindsey; N Morisaki; J M Stitts; R A Zager; D G Cornwell
Journal:  Lipids       Date:  1983-08       Impact factor: 1.880

10.  Fatty acid metabolism and cell proliferation. III. Effect of prostaglandin biosynthesis either from exogenous fatty acid or endogenous fatty acid release with hydralazine.

Authors:  N Morisaki; J A Lindsey; G E Milo; D G Cornwell
Journal:  Lipids       Date:  1983-05       Impact factor: 1.880
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