Literature DB >> 6413241

Infusion of a novel peptide, PHI, in man. Pharmacokinetics and effect on gastric secretion.

J M Allen, N D Christofides, G Gornacz, K Tatemoto, J H Baron, S R Bloom.   

Abstract

PHI, infused in man, achieved plateau plasma levels of 297 pmoles/1. The plasma half life was 3.1 min, metabolic clearance rate was 16.4 ml/kg/min and estimated volume of distribution was 73.2 ml/kg. No subjective side effects were noted during the infusion and there was no significant alteration in submaximal pentagastrin stimulated gastric acid or pepsin secretion.

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Year:  1983        PMID: 6413241     DOI: 10.1007/BF01943143

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  8 in total

1.  Infusion of vasoactive intestinal polypeptide in man: pharmacokinetics and effect on gastric acid secretion.

Authors:  M Holm-Bentzen; J Christiansen; B Petersen; J Fahrenkrug; A Schultz; P Kirkegaard
Journal:  Scand J Gastroenterol       Date:  1981-04       Impact factor: 2.423

2.  Actions of a newly isolated intestinal peptide PHI on pancreatic acini.

Authors:  R T Jensen; K Tatemoto; V Mutt; G F Lemp; J D Gardner
Journal:  Am J Physiol       Date:  1981-12

3.  PHI stimulates intestinal fluid secretion.

Authors:  M Ghiglione; N D Christofides; Y Yiangou; L O Uttenthal; S R Bloom
Journal:  Neuropeptides       Date:  1982-12       Impact factor: 3.286

4.  Actions of a new peptide from porcine intestine (PHI) on pancreatic secretion in the rat and turkey.

Authors:  R Dimaline; G J Dockray
Journal:  Life Sci       Date:  1980-11-24       Impact factor: 5.037

5.  Radioimmunoassay and intramural distribution of PHI-IR in human intestine.

Authors:  N D Christofides; Y Yiangou; E Aarons; G L Ferri; K Tatemoto; J M Polak; S R Bloom
Journal:  Dig Dis Sci       Date:  1983-06       Impact factor: 3.199

6.  Interaction of a newly isolated intestinal polypeptide (PHI) with glucose and arginine to effect the secretion of insulin and glucagon.

Authors:  J Szecówka; K Tatemoto; V Mutt; S Efendić
Journal:  Life Sci       Date:  1980-02-11       Impact factor: 5.037

7.  Isolation and characterization of the intestinal peptide porcine PHI (PHI-27), a new member of the glucagon--secretin family.

Authors:  K Tatemoto; V Mutt
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

8.  Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides.

Authors:  K Tatemoto; V Mutt
Journal:  Nature       Date:  1980-06-05       Impact factor: 49.962

  8 in total

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