| Literature DB >> 16435487 |
M Holm-Bentzen1, J Christiansen, B Petersen, J Fahrenkrug, A Schultz, P Kirkegaard.
Abstract
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers. On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h. Mean plasma VIP concentrations rose from 5.7 pmol/l to 28, 106 and 336 pmol/l during the VIP infusions. No significant changes in acid secretion occurred during VIP infusion as compared to infusion of pentagastrin alone, and no duodeno-gastric reflux was registered. Serum gastrin concentrations were unaltered during VIP infusion. Elimination of VIP was bi-exponential with half-lives of 2 and 21 min, respectively. Metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution 135 ml/kg.Entities:
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Year: 1981 PMID： 16435487 DOI： 10.3109/00365528109181992
Source DB: PubMed Journal: Scand J Gastroenterol ISSN： 0036-5521 Impact factor: 2.423