Literature DB >> 6407007

Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.

C Wood, S Tonegawa.   

Abstract

We have mapped 12 diversity (D) gene segments of mouse Ig heavy chains between 80 and 1 kilobases 5' to the four joining (JH) gene segments by molecular analysis of DNA clones isolated from recombinant phage and cosmid libraries. All identified D and JH segments are in the same 5'-3' orientation. The significance of these findings with respect to the joining mechanism for Ig gene segments is discussed.

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Year:  1983        PMID： 6407007      PMCID： PMC393967          DOI： 10.1073/pnas.80.10.3030

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Sequences at the somatic recombination sites of immunoglobulin light-chain genes.

Authors:  H Sakano; K Hüppi; G Heinrich; S Tonegawa
Journal:  Nature       Date:  1979-07-26       Impact factor: 49.962

2.  DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats.

Authors:  R Lenhard-Schuller; B Hohn; C Brack; M Hirama; S Tonegawa
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

3.  Cloning of an immunoglobulin variable region gene from mouse embryo.

Authors:  S Tonegawa; C Brack; N Hozumi; R Schuller
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

4.  Charon phages: safer derivatives of bacteriophage lambda for DNA cloning.

Authors:  F R Blattner; B G Williams; A E Blechl; K Denniston-Thompson; H E Faber; L Furlong; D J Grunwald; D O Kiefer; D D Moore; J W Schumm; E L Sheldon; O Smithies
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

5.  Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.

Authors:  H Sakano; R Maki; Y Kurosawa; W Roeder; S Tonegawa
Journal:  Nature       Date:  1980-08-14       Impact factor: 49.962

6.  An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.

Authors:  P Early; H Huang; M Davis; K Calame; L Hood
Journal:  Cell       Date:  1980-04       Impact factor: 41.582

7.  Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments.

Authors:  J Schilling; B Clevinger; J M Davie; L Hood
Journal:  Nature       Date:  1980-01-03       Impact factor: 49.962

8.  Exon shuffling generates an immunoglobulin heavy chain gene.

Authors:  R Maki; A Traunecker; H Sakano; W Roeder; S Tonegawa
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

9.  Plasmid screening at high colony density.

Authors:  D Hanahan; M Meselson
Journal:  Gene       Date:  1980-06       Impact factor: 3.688

10.  A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments.

Authors:  M Steinmetz; W Altenburger; H G Zachau
Journal:  Nucleic Acids Res       Date:  1980-04-25       Impact factor: 16.971
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  41 in total

1.  The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement.

Authors:  F Davodeau; M Difilippantonio; E Roldan; M Malissen; J L Casanova; C Couedel; J F Morcet; M Merkenschlager; A Nussenzweig; M Bonneville; B Malissen
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

Review 2.  Mouse chromosome 12.

Authors:  P D'Eustachio
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  Allelic polymorphism of mouse Igh-J locus, which encodes immunoglobulin heavy chain joining (JH) segments.

Authors:  M L Solin; M Kaartinen
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

4.  Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation.

Authors:  A Alessandrini; S V Desiderio
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

5.  Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.

Authors:  E H Brown; M A Iqbal; S Stuart; K S Hatton; J Valinsky; C L Schildkraut
Journal:  Mol Cell Biol       Date:  1987-01       Impact factor: 4.272

Review 6.  Genome folding through loop extrusion by SMC complexes.

Authors:  Iain F Davidson; Jan-Michael Peters
Journal:  Nat Rev Mol Cell Biol       Date:  2021-03-25       Impact factor: 94.444

7.  Cells use loop extrusion to weave and tie the genome.

Authors:  Leonid A Mirny
Journal:  Nature       Date:  2021-02-17       Impact factor: 49.962

8.  Immunoglobulin JH rearrangement in a T-cell line reflects fusion to the DH locus at a sequence lacking the nonamer recognition signal.

Authors:  S Gerondakis; O Bernard; S Cory; J M Adams
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

9.  Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells.

Authors:  H Kiyoi; T Naoe; K Horibe; R Ohno
Journal:  J Clin Invest       Date:  1992-03       Impact factor: 14.808

10.  Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies.

Authors:  D L Wood; C Coleclough
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205
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