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Literature DB >> 6774258

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.

H Sakano, R Maki, Y Kurosawa, W Roeder, S Tonegawa.

Abstract

At least two types of somatic recombination are necessary for the generation of a complete immunoglobulin gamma 2b gene from germ-line DNA sequences. The first type of recombination consists of the assembly of three separate DNA segments, each encoding a different part of the variable region. The second type of recombination replaces the exons coding for the constant region of the mu chain with those coding for the same region of the gamma 2b chain. The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms.

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Year: 1980 PMID： 6774258 DOI： 10.1038/286676a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

276 in total

1. Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins.

Authors: J E McElveen; P B Furtado; S J Smith; M R Clark; I Spendlove; H F Sewell; F Shakib
Journal: Mol Pathol Date: 2000-04

2. In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining.

Authors: Tadashi Nishihara; Fumikiyo Nagawa; Hirofumi Nishizumi; Masami Kodama; Satoshi Hirose; Reiko Hayashi; Hitoshi Sakano
Journal: Mol Cell Biol Date: 2004-05 Impact factor: 4.272

3. Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplification.

Authors: A H Liu; G Creadon; L J Wysocki
Journal: Proc Natl Acad Sci U S A Date: 1992-08-15 Impact factor: 11.205

Review 4. Mouse chromosome 12.

Authors: P D'Eustachio
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

5. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

Authors: S G Lebecque; P J Gearhart
Journal: J Exp Med Date: 1990-12-01 Impact factor: 14.307

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.

1. Characterisation of a mouse monoclonal anti-idiotype reactive with a V region sequence commonly used by human immunoglobulins.

2. In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining.

3. Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplification.

Review 4. Mouse chromosome 12.

5. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

6. Copy choice mechanism of immunoglobulin heavy-chain switch recombination.

7. Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

8. Fine-mapping of DNA damage and repair in specific genomic segments.

Review 9. Role of recombination activating genes in the generation of antigen receptor diversity and beyond.

10. Evolution of immunoglobulin genes: VH families in the amphibian Xenopus.