Literature DB >> 6405281

Chance, necessity and antibody gene dynamics.

C Coleclough.   

Abstract

Early in their development B lymphocytes commit themselves to the expression of only one immunoglobulin light-chain gene and only one heavy-chain gene out of the large numbers of available loci. Here I shall present the view that the initial selection of loci for expression is made by chance, whereas the exclusion of other loci from expression is a necessity imposed by the physiology of lymphocyte development.

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Year:  1983        PMID： 6405281     DOI： 10.1038/303023a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  20 in total

Review 1.  Receptor selection in B and T lymphocytes.

Authors:  D Nemazee
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

Review 2.  Epigenetics of haematopoietic cell development.

Authors:  Howard Cedar; Yehudit Bergman
Journal:  Nat Rev Immunol       Date:  2011-06-10       Impact factor: 53.106

3.  Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro.

Authors:  T Kinashi; K Inaba; T Tsubata; K Tashiro; R Palacios; T Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

4.  Genetics, chance, and morphogenesis.

Authors:  D M Kurnit; W M Layton; S Matthysse
Journal:  Am J Hum Genet       Date:  1987-12       Impact factor: 11.025

5.  Nonproductive kappa immunoglobulin genes: recombinational abnormalities and other lesions affecting transcription, RNA processing, turnover, and translation.

Authors:  D E Kelley; L M Wiedemann; A C Pittet; S Strauss; K J Nelson; J Davis; B Van Ness; R P Perry
Journal:  Mol Cell Biol       Date:  1985-07       Impact factor: 4.272

6.  Recombination between kappa chain genetic markers in the mouse.

Authors:  D M Gibson; S J MacLean; D Anctil; B J Mathieson
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

Review 7.  Epigenetic control of recombination in the immune system.

Authors:  Yehudit Bergman; Howard Cedar
Journal:  Semin Immunol       Date:  2010-09-15       Impact factor: 11.130

Review 8.  Role of recombination activating genes in the generation of antigen receptor diversity and beyond.

Authors:  Mayilaadumveettil Nishana; Sathees C Raghavan
Journal:  Immunology       Date:  2012-12       Impact factor: 7.397

9.  Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

Authors:  Laurent Verkoczy; Bao Duong; Patrick Skog; Djemel Aït-Azzouzene; Kamal Puri; José Luis Vela; David Nemazee
Journal:  J Immunol       Date:  2007-05-15       Impact factor: 5.422

10.  Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies.

Authors:  D L Wood; C Coleclough
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205
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