Literature DB >> 6403671

Decreased brain dopamine synthesis rate and increased [3H]spiroperidol binding in streptozotocin-diabetic rats.

M E Trulson, C D Himmel.   

Abstract

The rate of accumulation of 3,4-dihydroxy-phenylalanine following decarboxylase inhibition and of homovanillic acid following probenecid treatment were significantly decreased in streptozotocin-diabetic rats. These changes were observed in both the striatum and limbic forebrain. The Bmax for [3H]spiroperidol receptor binding was significantly increased in both brain regions. All of these neurochemical changes were reversed by insulin replacement therapy. Whether these neurochemical changes are attributable to chronic hyperglycemia or some other aspect of the diabetic state is not known.

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Year:  1983        PMID： 6403671     DOI： 10.1111/j.1471-4159.1983.tb13590.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  21 in total

1.  Insulin reverses anxiety-like behavior evoked by streptozotocin-induced diabetes in mice.

Authors:  Deepali Gupta; Mahesh Radhakrishnan; Yeshwant Kurhe
Journal:  Metab Brain Dis       Date:  2014-04-25       Impact factor: 3.584

2.  Striatal dopaminergic D1 and D2 receptors after intracerebroventricular application of alloxan and streptozocin in rat.

Authors:  M Salković; I Sabolić; Z Lacković
Journal:  J Neural Transm Gen Sect       Date:  1995

3.  The concentration of dopamine, 5-hydroxytryptamine, and some of their acid metabolites in the brain of genetically diabetic rats.

Authors:  R P Kwok; E K Walls; A V Juorio
Journal:  Neurochem Res       Date:  1985-05       Impact factor: 3.996

4.  Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia.

Authors:  Fernando Caravaggio; Margaret Hahn; Shinichiro Nakajima; Philip Gerretsen; Gary Remington; Ariel Graff-Guerrero
Journal:  Med Hypotheses       Date:  2015-06-24       Impact factor: 1.538

5.  Hypothalamic neuropeptide Y (NPY) and the attenuation of hyperphagia in streptozotocin diabetic rats treated with dopamine D1/D2 agonists.

Authors:  Dong-Yih Kuo
Journal:  Br J Pharmacol       Date:  2006-05-15       Impact factor: 8.739

6.  Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes.

Authors:  Bryan Cruz; Rodolfo J Flores; Kevin P Uribe; Evangelina J Espinoza; Charles T Spencer; Katherine M Serafine; Arbi Nazarian; Laura E O'Dell
Journal:  Neuropsychopharmacology       Date:  2019-01-07       Impact factor: 7.853

7.  Dopamine deficiency contributes to early visual dysfunction in a rodent model of type 1 diabetes.

Authors:  Moe H Aung; Han Na Park; Moon K Han; Tracy S Obertone; Jane Abey; Fazila Aseem; Peter M Thule; P Michael Iuvone; Machelle T Pardue
Journal:  J Neurosci       Date:  2014-01-15       Impact factor: 6.167

8.  Effect of diabetes on the enzymes of the cholinergic system of the rat brain.

Authors:  Z Z Wahba; K F Soliman
Journal:  Experientia       Date:  1988-09-15

9.  Enhanced dopamine D1 and D2 receptor gene expression in the hippocampus of hypoglycaemic and diabetic rats.

Authors:  Remya Robinson; Amee Krishnakumar; C S Paulose
Journal:  Cell Mol Neurobiol       Date:  2009-01-09       Impact factor: 5.046

10.  Reestablishment of the hyperglycemia to the normal levels seems not to be essential to the anxiolytic-like effect induced by insulin.

Authors:  Eder Gambeta; Camila Pasquini de Souza; Helen de Morais; Janaina Menezes Zanoveli
Journal:  Metab Brain Dis       Date:  2015-11-25       Impact factor: 3.584
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