Literature DB >> 2409457

The concentration of dopamine, 5-hydroxytryptamine, and some of their acid metabolites in the brain of genetically diabetic rats.

R P Kwok, E K Walls, A V Juorio.   

Abstract

This is a report of the concentrations of DA, DOPAC, HVA, 5-HT, and 5-HIAA in the brain of spontaneously diabetic male Wistar rats. These rats showed a marked increase in blood and urine glucose, polydipsia, polyuria, and weight loss that had an onset 11-23 days earlier. Controls were litter mates with no hyperglycemia, glucosuria or weight reduction. The spontaneously diabetic rats showed a significant reduction of DOPAC in the striatum, and DOPAC, HVA, and 5HIAA in the olfactory tubercles (to 69, 61, 62, and 65% of their respective controls). No changes were found in the concentrations of DA or 5-HT. Thus the spontaneously diabetic rats showed a marked reduction in striatal and mesolimbic DA and mesolimbic 5-HT metabolism. This reduction in metabolism could be the consequence of a reduction in the formation of DA and 5-HT.

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Year:  1985        PMID： 2409457     DOI： 10.1007/bf00964400

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  9 in total

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2.  Brain serotonin content: physiological regulation by plasma neutral amino acids.

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3.  Decreased brain dopamine synthesis rate and increased [3H]spiroperidol binding in streptozotocin-diabetic rats.

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Journal:  J Neurochem       Date:  1983-05       Impact factor: 5.372

4.  Differential effects of insulin on brain monoamine metabolism in rats.

Authors:  U Berggren; J Engel; S Liljequist
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1983-07

5.  Increase in large neutral amino acid transport into brain by insulin.

Authors:  M G De Montis; M C Olianas; B Haber; A Tagliamonte
Journal:  J Neurochem       Date:  1978-01       Impact factor: 5.372

6.  Acute changes in brain tryptophan and serotonin after carbohydrate or protein ingestion by diabetic rats.

Authors:  E A Crandall; J D Fernstrom
Journal:  Diabetes       Date:  1980-06       Impact factor: 9.461

7.  Simultaneous measurement of tyrosine, tryptophan and related monoamines for determination of neurotransmitter turnover in discrete rat brain regions by liquid chromatography with electrochemical detection.

Authors:  S M Lasley; I A Michaelson; R D Greenland; P M McGinnis
Journal:  J Chromatogr       Date:  1984-01-13

8.  Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents.

Authors:  J Havrankova; J Roth; M J Brownstein
Journal:  J Clin Invest       Date:  1979-08       Impact factor: 14.808

9.  Dopamine receptor binding is increased in diabetic rats.

Authors:  D Lozovsky; C F Saller; I J Kopin
Journal:  Science       Date:  1981-11-27       Impact factor: 47.728
  9 in total
  6 in total

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6.  Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats.

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  6 in total

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