Literature DB >> 3416989

Effect of diabetes on the enzymes of the cholinergic system of the rat brain.

Z Z Wahba1, K F Soliman.   

Abstract

Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities were determined in several brain regions of normal and streptozotocin-induced diabetic rats. The diabetic rats exhibited significant increase in ChAT activity (p less than 0.05) in all brain regions studied except for the cortex and the midbrain. Meanwhile, the diabetes condition was associated with significant increase (p less than 0.05) in AChE activity of the bulbus olfactorius, medulla oblongata and cerebellum. These data suggest that uncontrolled diabetes is associated with significant alterations in the brain cholinergic systems.

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Year:  1988        PMID： 3416989     DOI： 10.1007/BF01959147

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  23 in total

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Journal:  Arch Neurol       Date:  1981-01

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Journal:  Diabetes       Date:  1982       Impact factor: 9.461

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Authors:  E Niakan; Y Harati; J P Comstock
Journal:  Metabolism       Date:  1986-03       Impact factor: 8.694

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Authors:  C S Mayanil; S M Kazmi; N Z Baquer
Journal:  J Neurochem       Date:  1982-01       Impact factor: 5.372

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Authors:  E RESKE-NIELSEN; K LUNDBAEK
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  5 in total

1.  Diabetes induced by streptozotocin causes reduced Na-K ATPase in the brain.

Authors:  S F Leong; T K Leung
Journal:  Neurochem Res       Date:  1991-10       Impact factor: 3.996

2.  Choline-deprivation alters crucial brain enzyme activities in a rat model of diabetic encephalopathy.

Authors:  Charis Liapi; Argyro Kyriakaki; Apostolos Zarros; Panagiota Galanopoulou; Hussam Al-Humadi; Ismene Dontas; Konstantinos Voumvourakis; Stylianos Tsakiris
Journal:  Metab Brain Dis       Date:  2010-09-14       Impact factor: 3.584

3.  Effects of adult-onset streptozotocin-induced diabetes on the rat brain antioxidant status and the activities of acetylcholinesterase, (Na(+),K (+))- and Mg(2+)-ATPase: modulation by L-cysteine.

Authors:  Apostolos Zarros; Charis Liapi; Panagiota Galanopoulou; Kyriakoula Marinou; Zois Mellios; Nikolina Skandali; Hussam Al-Humadi; Foteini Anifantaki; Elena Gkrouzman; Stylianos Tsakiris
Journal:  Metab Brain Dis       Date:  2009-03-19       Impact factor: 3.584

4.  Effect of stress on choline acetyltransferase activity of the brain and the adrenal of the rat.

Authors:  Z Z Wahba; K F Soliman
Journal:  Experientia       Date:  1992-03-15

5.  Effects of streptozotocin-induced diabetes on acetylcholine metabolism in rat brain.

Authors:  B Welsh; L Wecker
Journal:  Neurochem Res       Date:  1991-04       Impact factor: 3.996
  5 in total

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