Literature DB >> 6402160

Maturity onset diabetes of the young is not linked to the insulin gene.

J I Bell, J S Wainscoat, J M Old, C Chlouverakis, H Keen, R C Turner, D J Weatherall.   

Abstract

Maturity onset diabetes of the young is inherited as an autosomal dominant condition. Two families with the disease were studied to determine whether the inheritance of this type of diabetes was linked to the insulin gene. A cloned insulin gene probe was hybridised to DNA from the family members and the insulin gene on each chromosome identified by a different fragment length polymorphism. The results showed no linkage between the insulin gene and the inheritance of maturity onset diabetes of the young.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6402160      PMCID： PMC1546839          DOI： 10.1136/bmj.286.6365.590

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN： 0267-0623


  14 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

Authors:  G I Bell; J H Karam; W J Rutter
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

3.  Polymorphism in the 5'-flanking region of the human insulin gene and its possible relation to type 2 diabetes.

Authors:  P Rotwein; R Chyn; J Chirgwin; B Cordell; H M Goodman; M A Permut
Journal:  Science       Date:  1981-09-04       Impact factor: 47.728

4.  Sequence of the human insulin gene.

Authors:  G I Bell; R L Pictet; W J Rutter; B Cordell; E Tischer; H M Goodman
Journal:  Nature       Date:  1980-03-06       Impact factor: 49.962

5.  Mild familial diabetes with dominant inheritance.

Authors:  R B Tattersall
Journal:  Q J Med       Date:  1974-04

6.  A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people.

Authors:  R B Tattersall; S S Fajans
Journal:  Diabetes       Date:  1975-01       Impact factor: 9.461

7.  The various faces of diabetes in the young: changing concepts.

Authors:  S S Fajans; J C Floyd; R B Tattersall; J R Williamson; S Pek; C I Taylor
Journal:  Arch Intern Med       Date:  1976-02

8.  The genetics of the glucose intolerance disorders.

Authors:  J I Rotter; D L Rimoin
Journal:  Am J Med       Date:  1981-01       Impact factor: 4.965

9.  Plasma glucose, insulin, glucagon, and growth hormone in kindreds with maturity-onset type of hyperglycemia in young people.

Authors:  J Barbosa; R Ramsay; F C Goetz
Journal:  Ann Intern Med       Date:  1978-05       Impact factor: 25.391

Review 10.  Diabetes: the genetic connections.

Authors:  D A Pyke
Journal:  Diabetologia       Date:  1979-12       Impact factor: 10.122
View more
  9 in total

1.  Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth.

Authors:  S O'Rahilly; P Patel; O J Lehmann; A Tybjaerg-Hansen; J Nerup; R C Turner; J S Wainscoat
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

2.  Linkage analysis of the human insulin receptor gene and maturity onset diabetes of the young.

Authors:  S C Elbein; I Borecki; L Corsetti; S S Fajans; A T Hansen; J Nerup; M Province; M A Permutt
Journal:  Diabetologia       Date:  1987-08       Impact factor: 10.122

3.  Genetic analysis of the hypervariable region flanking the human insulin gene.

Authors:  P Rotwein; S Yokoyama; D K Didier; J M Chirgwin
Journal:  Am J Hum Genet       Date:  1986-09       Impact factor: 11.025

4.  The genetic predisposition to fibrocalculous pancreatic diabetes.

Authors:  P K Kambo; G A Hitman; V Mohan; A Ramachandran; C Snehalatha; S Suresh; K Metcalfe; B K Ryait; M Viswanathan
Journal:  Diabetologia       Date:  1989-01       Impact factor: 10.122

5.  Linkage analysis of the human insulin receptor gene in type 2 (non-insulin-dependent) diabetic families and a family with maturity onset diabetes of the young.

Authors:  S O'Rahilly; R C Trembath; P Patel; D J Galton; R C Turner; J S Wainscoat
Journal:  Diabetologia       Date:  1988-11       Impact factor: 10.122

Review 6.  Insulin-gene flanking sequences, diabetes mellitus and atherosclerosis: a review.

Authors:  T Mandrup-Poulsen; D Owerbach; J Nerup; K Johansen; J Ingerslev; A T Hansen
Journal:  Diabetologia       Date:  1985-08       Impact factor: 10.122

7.  Diabetes mellitus, atherosclerosis, and the 5' flanking polymorphism of the human insulin gene.

Authors:  T Mandrup-Poulsen; D Owerbach; J Nerup; K Johansen; A Tybjaerg Hansen
Journal:  J Inherit Metab Dis       Date:  1986       Impact factor: 4.982

8.  Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians.

Authors:  W C Knowler; D J Pettitt; B Vasquez; P S Rotwein; T L Andreone; M A Permutt
Journal:  J Clin Invest       Date:  1984-12       Impact factor: 14.808

9.  Possible correlation between non-insulin dependent diabetes mellitus (NIDDM) and restriction fragment length polymorphism (RFLP) of the 5'-flanking region of insulin gene in Korean diabetic population.

Authors:  S W Kim; I M Yang; J W Kim; Y S Kim; Y K Choi
Journal:  Korean J Intern Med       Date:  1987-07       Impact factor: 2.884
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.