Literature DB >> 6272317

Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

G I Bell, J H Karam, W J Rutter.   

Abstract

The length of a segment of DNA associated with the human insulin gene, which has been localized to the short arm of chromosome 11, is heterozygous in 63% of 52 individuals analyzed. This polymorphic region is approximately 500 base pairs from the nucleotide encoding the 5' end of insulin mRNA. The polymorphism appears to be due to an insertion or deletion of DNA sequences so that DNA fragments of different length are generated when DNA from a heterozygous individual is digested with selected restriction endonucleases.

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Year:  1981        PMID： 6272317      PMCID： PMC348853          DOI： 10.1073/pnas.78.9.5759

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
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2.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

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3.  Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

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Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

Review 4.  The molecular genetics of human hemoglobins.

Authors:  T Maniatis; E F Fritsch; J Lauer; R M Lawn
Journal:  Annu Rev Genet       Date:  1980       Impact factor: 16.830

5.  Familial hyperproinsulinemia: partial characterization of circulating proinsulin-like material.

Authors:  K H Gabbay; R M Bergenstal; J Wolff; M E Mako; A H Rubenstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

6.  Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

Authors:  Y W Kan; A M Dozy
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

7.  Polymorphisms in the chromosomal locations of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila.

Authors:  E Strobel; P Dunsmuir; G M Rubin
Journal:  Cell       Date:  1979-06       Impact factor: 41.582

8.  Evidence for transposition of dispersed repetitive DNA families in yeast.

Authors:  J R Cameron; E Y Loh; R W Davis
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

9.  A structurally abnormal insulin causing human diabetes.

Authors:  H Tager; B Given; D Baldwin; M Mako; J Markese; A Rubenstein; J Olefsky; M Kobayashi; O Kolterman; R Poucher
Journal:  Nature       Date:  1979-09-13       Impact factor: 49.962

10.  DNA sequence variants in the G gamma-, A gamma-, delta- and beta-globin genes of man.

Authors:  A J Jeffreys
Journal:  Cell       Date:  1979-09       Impact factor: 41.582
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  324 in total

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3.  PCR can add to detection of pneumococcal disease in pneumonic patients receiving antibiotics at admission.

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4.  A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays.

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5.  Genetic evidence on the origins of Indian caste populations.

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7.  Structural analysis of insulin minisatellite alleles reveals unusually large differences in diversity between Africans and non-Africans.

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Journal:  Am J Hum Genet       Date:  2002-10-28       Impact factor: 11.025

8.  A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.

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9.  Heterogeneity in the gene locus for steroid 21-hydroxylase deficiency.

Authors:  G Rumsby; A H Fielder; W M Hague; J W Honour
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10.  Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation.

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