Literature DB >> 6394334

99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical.

W A Volkert, T J Hoffman, R M Seger, D E Troutner, R A Holmes.   

Abstract

Propylene amine oxime (PnAO) forms a neutral lipid soluble complex with 99mTc. 99mTc-PnAO can be prepared by simple reduction of 99mTc-pertechnetate with stannous ion in the presence of excess PnAO in saline at or near neutral pH. This agent will passively penetrate biological membranes including the intact blood-brain barrier (BBB) as evidenced by the high brain uptake observed shortly after IV injection. The first-pass extraction efficiency in baboons was estimated to be 80% at normal blood flow. This agent or a derivatized form of 99mTc-PnAO may be useful in assessment of regional cerebral blood flow (rCBF) in humans.

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Year:  1984        PMID： 6394334     DOI： 10.1007/BF00263256

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  20 in total

1.  Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled water.

Authors:  M E Raichle; J O Eichling; M G Straatmann; M J Welch; K B Larson; M M Ter-Pogossian
Journal:  Am J Physiol       Date:  1976-02

2.  Radioiodine-labeled N,N-dimethyl-N'-(2-hydroxy-3-alkyl-5-iodobenzyl)-1,3-propanediamines for brain perfusion imaging.

Authors:  K M Tramposch; H F Kung; M Blau
Journal:  J Med Chem       Date:  1983-02       Impact factor: 7.446

3.  Relationship between lipophilicity and brain extraction of C-11-labeled radiopharmaceuticals.

Authors:  D D Dishino; M J Welch; M R Kilbourn; M E Raichle
Journal:  J Nucl Med       Date:  1983-11       Impact factor: 10.057

4.  Initial experience with SPECT (single-photon computerized tomography) of the brain using N-isopropyl I-123 p-iodoamphetamine: concise communication.

Authors:  T C Hill; B L Holman; R Lovett; D H O'Leary; D Front; P Magistretti; R E Zimmerman; S Moore; M E Clouse; J L Wu; T H Lin; R M Baldwin
Journal:  J Nucl Med       Date:  1982-03       Impact factor: 10.057

5.  Technetium-99m-kethoxal-bis(thiosemicarbazone), an uncharged complex with a tetravalent 99mTc state, and its excretion into the bile.

Authors:  A Yokoyama; Y Terauchi; K Horiuchi; H Tanaka; T Odori
Journal:  J Nucl Med       Date:  1976-09       Impact factor: 10.057

6.  Complexing of Tc-99m with cyclam: concise communication.

Authors:  D E Troutner; J Simon; A R Ketring; W Volkert; R A Holmes
Journal:  J Nucl Med       Date:  1980-05       Impact factor: 10.057

7.  A neutral lipophilic complex of 99mTc with a multidentate amine oxime.

Authors:  D E Troutner; W A Volkert; T J Hoffman; R A Holmes
Journal:  Int J Appl Radiat Isot       Date:  1984-06

8.  Synthesis and biodistribution of neutral lipid-soluble Tc-99m complexes that cross the blood-brain barrier.

Authors:  H F Kung; M Molnar; J Billings; R Wicks; M Blau
Journal:  J Nucl Med       Date:  1984-03       Impact factor: 10.057

9.  N-isopropyl(I-123)p-iodoamphetamine brain scans with single-photon emission tomography: discordance with transmission computed tomography.

Authors:  R G Lee; T C Hill; B L Holman; M E Clouse
Journal:  Radiology       Date:  1982-12       Impact factor: 11.105

10.  Regional intracellular pH shift: a proposed new mechanism for radiopharmaceutical uptake in brain and other tissues.

Authors:  H F Kung; M Blau
Journal:  J Nucl Med       Date:  1980-02       Impact factor: 10.057
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  10 in total

Review 1.  Single-photon emission computed tomography in neurotherapeutics.

Authors:  Michael D Devous
Journal:  NeuroRx       Date:  2005-04

Review 2.  A brief overview of metal complexes as nuclear imaging agents.

Authors:  Douglas S MacPherson; Kimberly Fung; Brendon E Cook; Lynn C Francesconi; Brian M Zeglis
Journal:  Dalton Trans       Date:  2019-10-07       Impact factor: 4.390

3.  99mTc-HMPAO as a tumour blood flow agent.

Authors:  P A Hammersley; V R McCready; J W Babich; G Coghlan
Journal:  Eur J Nucl Med       Date:  1987

4.  Determination of cerebral perfusion by means of planar brain scintigraphy and 99mTc-HMPAO in brain death, persistent vegetative state and severe coma.

Authors:  H P Schlake; I G Böttger; K H Grotemeyer; I W Husstedt; W Brandau; O Schober
Journal:  Intensive Care Med       Date:  1992       Impact factor: 17.440

5.  Evaluation of technetium-99m exametazime stabilised with cobalt chloride as a blood flow tracer in focal cerebral ischaemia.

Authors:  G Gartshore; P Bannan; J Patterson; B Higley; J McCulloch
Journal:  Eur J Nucl Med       Date:  1994-09

6.  Comparative evaluation of SPECT, CT and CW Doppler data in patients with ischemic lesions of the brain.

Authors:  M Zanardi; M Rossi; M Bonamini; P Fiorio; M Caputo; A Manzara
Journal:  Ital J Neurol Sci       Date:  1991-08

7.  The behavior of 99mTc-hexamethylpropyleneamineoxime (99mTc-HMPAO) in blood and brain.

Authors:  K Nakamura; Y Tukatani; A Kubo; S Hashimoto; Y Terayama; T Amano; F Goto
Journal:  Eur J Nucl Med       Date:  1989

8.  Synthesis, radiochemistry and biological evaluation of a new somatostatin analogue (SDZ 219-387) labelled with technetium-99m.

Authors:  T Maina; B Stolz; R Albert; C Bruns; P Koch; H Mäcke
Journal:  Eur J Nucl Med       Date:  1994-05

9.  99mTc-HM-PAO for leukocyte labeling--experimental comparison with 111In oxine in dogs.

Authors:  J G McAfee; G Subramanian; G Gagne; R F Schneider; C Zapf-Longo
Journal:  Eur J Nucl Med       Date:  1987

Review 10.  Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems.

Authors:  W C Eckelman
Journal:  Eur J Nucl Med       Date:  1995-03
  10 in total

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