Literature DB >> 6610648

A neutral lipophilic complex of 99mTc with a multidentate amine oxime.

D E Troutner, W A Volkert, T J Hoffman, R A Holmes.   

Abstract

Propylene amine oxime, 3,3'-(1,3-propanediyldiimino)bis(3-methyl-2-butanone)dioxime, (PnAO) forms a neutral lipophilic complex with 99mTc in greater than 95% yield at room temperature at pH 5-10. The complex can be prepared with generator produced 99mTc using 10(-5) M SnC4H4O6 as the reducing agent at ligand concentrations as low as 3 X 10(-5) M. It is stable in saline solutions for as long as 24 h. [99mTc]PnAO may be useful as an imaging agent which passively diffuses across the blood brain barrier.

Entities:  

Mesh：

Year:  1984        PMID： 6610648     DOI： 10.1016/0020-708x(84)90165-0

Source DB:  PubMed          Journal:  Int J Appl Radiat Isot        ISSN： 0020-708X


  11 in total

1.  Evaluation of novel 99mTc(I)-labeled homobivalent α-melanocyte-stimulating hormone analogs for melanocortin-1 receptor targeting.

Authors:  Maurício Morais; Paula D Raposinho; Maria Cristina Oliveira; João D G Correia; Isabel Santos
Journal:  J Biol Inorg Chem       Date:  2012-04       Impact factor: 3.358

2.  Nuclear targeting with cell-specific multifunctional tricarbonyl M(I) (M is Re, (99m)Tc) complexes: synthesis, characterization, and cell studies.

Authors:  Teresa Esteves; Fernanda Marques; António Paulo; José Rino; Prasant Nanda; C Jeffrey Smith; Isabel Santos
Journal:  J Biol Inorg Chem       Date:  2011-06-25       Impact factor: 3.358

3.  Synthesis and biological evaluation of tricarbonyl Re(I) and Tc(I) complexes anchored by poly(azolyl)borates: application on the design of radiopharmaceuticals for the targeting of 5-HT1A receptors.

Authors:  Raquel Garcia; Lurdes Gano; Leonor Maria; António Paulo; Isabel Santos; Hartmut Spies
Journal:  J Biol Inorg Chem       Date:  2006-07-06       Impact factor: 3.358

4.  Evaluation of technetium 99m cyclobutylpropylene amine oxime as a potential brain perfusion imaging agent for SPET.

Authors:  L Bacciottini; F Lunghi; A Pupi; C Bonino; A R Formiconi; M T De Cristofaro; A R Petti; U Meldolesi
Journal:  Eur J Nucl Med       Date:  1990

5.  Formulation of a single-component kit for the preparation of technetium-99m labelled ethyl cysteinate dimer: biological and clinical evaluation.

Authors:  A Afshan; M Jehangir; M Ashraf; A Waqar; E Chiotellis
Journal:  Eur J Nucl Med       Date:  1994-09

6.  Synthesis, radiochemistry and biological evaluation of a new somatostatin analogue (SDZ 219-387) labelled with technetium-99m.

Authors:  T Maina; B Stolz; R Albert; C Bruns; P Koch; H Mäcke
Journal:  Eur J Nucl Med       Date:  1994-05

Review 7.  Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems.

Authors:  W C Eckelman
Journal:  Eur J Nucl Med       Date:  1995-03

8.  99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical.

Authors:  W A Volkert; T J Hoffman; R M Seger; D E Troutner; R A Holmes
Journal:  Eur J Nucl Med       Date:  1984

9.  A quinazoline-derivative DOTA-type gallium(III) complex for targeting epidermal growth factor receptors: synthesis, characterisation and biological studies.

Authors:  Raquel Garcia; Petra Fousková; Lurdes Gano; António Paulo; Paula Campello; Eva Tóth; Isabel Santos
Journal:  J Biol Inorg Chem       Date:  2008-11-13       Impact factor: 3.358

10.  Synthesis and Biological Evaluation of 99mTc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria.

Authors:  Diogo Figueiredo; Célia Fernandes; Francisco Silva; Elisa Palma; Paula Raposinho; Ana Belchior; Pedro Vaz; António Paulo
Journal:  Molecules       Date:  2021-01-15       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.