Literature DB >> 6393054

Nucleotide sequence of the yeast regulatory gene GAL80.

Y Nogi, T Fukasawa.   

Abstract

The GAL80 gene in Saccharomyces cerevisiae encodes a negative regulatory protein for the set of inducible genes involving metabolism of galactose and melibiose. We have determined the nucleotide sequence of GAL80 and its flanking regions and assigned the 5' end of its mRNA to the sequence. The deduced coding sequence for GAL80 protein contains 1305 nucleotides and the calculated molecular weight of the peptide chain is 48309. The 5' end of the GAL80 mRNA maps about 67 nucleotides upstream from the translation initiating ATG. We have also determined the nucleotide sequence of uninducible alleles GAL80S-0, GAL80S-1 and GAL80S-2, and found single base substitution in each of these mutant genes which would lead to alteration of amino acid in GAL80 protein.

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Year:  1984        PMID： 6393054      PMCID： PMC320461          DOI： 10.1093/nar/12.24.9287

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  38 in total

1.  Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form.

Authors:  D B Clewell; D R Helinski
Journal:  Proc Natl Acad Sci U S A       Date:  1969-04       Impact factor: 11.205

2.  Structure of the DNA-binding region of lac repressor inferred from its homology with cro repressor.

Authors:  B W Matthews; D H Ohlendorf; W F Anderson; Y Takeda
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

3.  The operator-binding domain of lambda repressor: structure and DNA recognition.

Authors:  C O Pabo; M Lewis
Journal:  Nature       Date:  1982-07-29       Impact factor: 49.962

4.  Sea urchin histone mRNA termini are located in gene regions downstream from putative regulatory sequences.

Authors:  C Hentschel; J C Irminger; P Bucher; M L Birnstiel
Journal:  Nature       Date:  1980-05-15       Impact factor: 49.962

5.  The nucleotide sequence of the HIS4 region of yeast.

Authors:  T F Donahue; P J Farabaugh; G R Fink
Journal:  Gene       Date:  1982-04       Impact factor: 3.688

6.  Interaction of super-repressible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae.

Authors:  Y Nogi; K Matsumoto; A Toh-e; Y Oshima
Journal:  Mol Gen Genet       Date:  1977-04-29

7.  DNA sequence required for efficient transcription termination in yeast.

Authors:  K S Zaret; F Sherman
Journal:  Cell       Date:  1982-03       Impact factor: 41.582

8.  Regulation of expression of the galactose gene cluster in Saccharomyces cerevisiae. II. The isolation and dosage effect of the regulatory gene GAL80.

Authors:  Y Nogi; H Shimada; Y Matsuzaki; H Hashimoto; T Fukasawa
Journal:  Mol Gen Genet       Date:  1984

9.  The structure of the yeast ribosomal RNA genes. I. The complete nucleotide sequence of the 18S ribosomal RNA gene from Saccharomyces cerevisiae.

Authors:  P M Rubtsov; M M Musakhanov; V M Zakharyev; A S Krayev; K G Skryabin; A A Bayev
Journal:  Nucleic Acids Res       Date:  1980-12-11       Impact factor: 16.971

10.  DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA.

Authors:  J I Stiles; J W Szostak; A T Young; R Wu; S Consaul; F Sherman
Journal:  Cell       Date:  1981-07       Impact factor: 41.582
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  34 in total

1.  Detecting interactions between eukaryotic proteins in bacteria.

Authors:  J Ma
Journal:  Gene Expr       Date:  1992

2.  The qa repressor gene of Neurospora crassa: wild-type and mutant nucleotide sequences.

Authors:  L Huiet; N H Giles
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

3.  Mutational hypersensitivity of a gene regulatory protein: Saccharomyces cerevisiae Gal80p.

Authors:  Karsten Melcher
Journal:  Genetics       Date:  2005-07-05       Impact factor: 4.562

Review 4.  Gene organization and regulation in the qa (quinic acid) gene cluster of Neurospora crassa.

Authors:  N H Giles; M E Case; J Baum; R Geever; L Huiet; V Patel; B Tyler
Journal:  Microbiol Rev       Date:  1985-09

5.  Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes.

Authors:  P M Sharp; T M Tuohy; K R Mosurski
Journal:  Nucleic Acids Res       Date:  1986-07-11       Impact factor: 16.971

Review 6.  Regulation of sugar utilization in Saccharomyces species.

Authors:  M Carlson
Journal:  J Bacteriol       Date:  1987-11       Impact factor: 3.490

Review 7.  A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae.

Authors:  M Johnston
Journal:  Microbiol Rev       Date:  1987-12

8.  Analysis of the galactose signal transduction pathway in Saccharomyces cerevisiae: interaction between Gal3p and Gal80p.

Authors:  T Suzuki-Fujimoto; M Fukuma; K I Yano; H Sakurai; A Vonika; S A Johnston; T Fukasawa
Journal:  Mol Cell Biol       Date:  1996-05       Impact factor: 4.272

9.  Interaction between transcriptional activator protein LAC9 and negative regulatory protein GAL80.

Authors:  J M Salmeron; S D Langdon; S A Johnston
Journal:  Mol Cell Biol       Date:  1989-07       Impact factor: 4.272

10.  Identification of a yeast protein with properties similar to those of the immunoglobulin heavy-chain enhancer-binding protein NF-muE3.

Authors:  H Beckmann; T Kadesch
Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272
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