Literature DB >> 6384726

Mutation to rifampicin resistance at the beginning of the RNA polymerase beta subunit gene in Escherichia coli.

N A Lisitsyn, E D Sverdlov, E P Moiseyeva, O N Danilevskaya, V G Nikiforov.   

Abstract

The unusual recombinant plasmid pRC19 carrying the N-terminal fragment of the Escherichia coli RNA polymerase rpoB gene was found to specify high level rifampicin resistance of E. coli cells. Sequence analysis of this plasmid revealed one substitution only: transversion G----T, leading to amino acid substitution Val146----Phe. This mutational change marks the second domain of the beta subunit involved in rifampicin binding.

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Year:  1984        PMID： 6384726     DOI： 10.1007/bf00334112

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  7 in total

1.  [Genetic study of mutations changing the dominance of alleles of sensitivity of Escherichia coli K-12 RNA polymerase to rifampicin and streptolydigin].

Authors:  S Z Mindlin; O N Danilevskaia; V V Vel'kov; E V Sokolova
Journal:  Genetika       Date:  1973-12

2.  Primary structure of Escherichia coli RNA polymerase nucleotide substitution in the beta subunit gene of the rifampicin resistant rpoB255 mutant.

Authors:  G S Monastyrskaya; V V Gubanov; V M Lipkin; E D Sverdlov; I F Kiver; I A Bass; S Z Mindlin; O N Danilevskaya; R B Khesin
Journal:  Mol Gen Genet       Date:  1981

3.  The primary structure of Escherichia coli RNA polymerase. Nucleotide sequence of the rpoB gene and amino-acid sequence of the beta-subunit.

Authors:  Y A Ovchinnikov; G S Monastyrskaya; V V Gubanov; S O Guryev; N N Modyanov; V A Grinkevich; I A Makarova; T V Marchenko; I N Polovnikova; V M Lipkin; E D Sverdlov
Journal:  Eur J Biochem       Date:  1981-06-01

4.  [Nucleotide substitutions in the rpoB gene leading to rifampicin resistance of E. coli RNA polymerase].

Authors:  N A Lisitsyn; S O Gur'ev; E D Sverdlov; E P Moiseeva; V G Nikiforov
Journal:  Bioorg Khim       Date:  1984-01

5.  RNA polymerase rifampicin resistance mutations in Escherichia coli: sequence changes and dominance.

Authors:  Y A Ovchinnikov; G S Monastyrskaya; S O Guriev; N F Kalinina; E D Sverdlov; A I Gragerov; I A Bass; I F Kiver; E P Moiseyeva; V N Igumnov; S Z Mindlin; V G Nikiforov; R B Khesin
Journal:  Mol Gen Genet       Date:  1983

6.  Genetic studies on the beta subunit of Escherichia coli RNA polymerase. III. Analysis of low-level rifampicin-resistant mutants.

Authors:  C M Boothroyd; R M Malet; V Nene; R E Glass
Journal:  Mol Gen Genet       Date:  1983

7.  Primary structure of an EcoRI fragment of lambda imm434 DNA containing regions cI-cro of phage 434 and cII-o of phage lambda.

Authors:  Y A Ovchinnikov; S O Guryev; A S Krayev; G S Monastyrskaya; K G Skryabin; E D Sverdlov; V M Zakharyev; A A Bayev
Journal:  Gene       Date:  1979-07       Impact factor: 3.688
  7 in total
  33 in total

1.  Green fluorescent protein as a marker in Rickettsia typhi transformation.

Authors:  J M Troyer; S Radulovic; A F Azad
Journal:  Infect Immun       Date:  1999-07       Impact factor: 3.441

2.  Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis.

Authors:  M Heep; U Rieger; D Beck; N Lehn
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

3.  Mutations at four distinct regions of the rpoB gene can reduce the susceptibility of Helicobacter pylori to rifamycins.

Authors:  M Heep; S Odenbreit; D Beck; J Decker; E Prohaska; U Rieger; N Lehn
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

4.  RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.

Authors:  A O'Neill; B Oliva; C Storey; A Hoyle; C Fishwick; I Chopra
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191

5.  Update on rifampin resistance in the Legionellaceae.

Authors:  A Serr; B F Koenig; M Heep; K Nielsen; J M Bangsborg
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

6.  Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics.

Authors:  Ming Xu; Yan Ning Zhou; Beth P Goldstein; Ding Jun Jin
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

Review 7.  Structural perspective on mutations affecting the function of multisubunit RNA polymerases.

Authors:  Vincent Trinh; Marie-France Langelier; Jacques Archambault; Benoit Coulombe
Journal:  Microbiol Mol Biol Rev       Date:  2006-03       Impact factor: 11.056

8.  The rpoB gene of Mycobacterium tuberculosis.

Authors:  L P Miller; J T Crawford; T M Shinnick
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

9.  Isolation and characterization of RNA polymerase rpoB mutations that alter transcription slippage during elongation in Escherichia coli.

Authors:  Yan Ning Zhou; Lucyna Lubkowska; Monica Hui; Carolyn Court; Shuo Chen; Donald L Court; Jeffrey Strathern; Ding Jun Jin; Mikhail Kashlev
Journal:  J Biol Chem       Date:  2012-12-05       Impact factor: 5.157

10.  Mu-induced rifamycin-resistant mutations not located in the rpoB gene of Escherichia coli.

Authors:  M C Kollenda; D Kamp; G R Hartmann
Journal:  Mol Gen Genet       Date:  1986-07
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