Literature DB >> 10722516

Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis.

M Heep1, U Rieger, D Beck, N Lehn.   

Abstract

A clinical isolate of Helicobacter pylori that developed resistance to rifabutin during therapy carried an rpoB gene that retained a wild-type cluster region sequence but had acquired a novel codon 149 (V149F) mutation. In transformation experiments, the mutation was shown to confer high-level rifabutin resistance. The equivalent mutation (V176F) was present in several resistant isolates of Mycobacterium tuberculosis.

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Year:  2000        PMID： 10722516      PMCID： PMC89817          DOI： 10.1128/AAC.44.4.1075-1077.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Rifampin and rifabutin resistance mechanism in Helicobacter pylori.

Authors:  M Heep; D Beck; E Bayerdörffer; N Lehn
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

2.  The complete genome sequence of the gastric pathogen Helicobacter pylori.

Authors:  J F Tomb; O White; A R Kerlavage; R A Clayton; G G Sutton; R D Fleischmann; K A Ketchum; H P Klenk; S Gill; B A Dougherty; K Nelson; J Quackenbush; L Zhou; E F Kirkness; S Peterson; B Loftus; D Richardson; R Dodson; H G Khalak; A Glodek; K McKenney; L M Fitzegerald; N Lee; M D Adams; E K Hickey; D E Berg; J D Gocayne; T R Utterback; J D Peterson; J M Kelley; M D Cotton; J M Weidman; C Fujii; C Bowman; L Watthey; E Wallin; W S Hayes; M Borodovsky; P D Karp; H O Smith; C M Fraser; J C Venter
Journal:  Nature       Date:  1997-08-07       Impact factor: 49.962

3.  Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis.

Authors:  B Yang; H Koga; H Ohno; K Ogawa; M Fukuda; Y Hirakata; S Maesaki; K Tomono; T Tashiro; S Kohno
Journal:  J Antimicrob Chemother       Date:  1998-11       Impact factor: 5.790

4.  Treatment of antibiotic-resistant Helicobacter pylori.

Authors:  F Perri; V Festa; A Andriulli
Journal:  N Engl J Med       Date:  1998-07-02       Impact factor: 91.245

5.  Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhi.

Authors:  J M Troyer; S Radulovic; S G Andersson; A F Azad
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

6.  Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis.

Authors:  A Telenti; P Imboden; F Marchesi; D Lowrie; S Cole; M J Colston; L Matter; K Schopfer; T Bodmer
Journal:  Lancet       Date:  1993-03-13       Impact factor: 79.321

7.  Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas.

Authors:  V Kapur; L L Li; S Iordanescu; M R Hamrick; A Wanger; B N Kreiswirth; J M Musser
Journal:  J Clin Microbiol       Date:  1994-04       Impact factor: 5.948

8.  Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Greece.

Authors:  P Matsiota-Bernard; G Vrioni; E Marinis
Journal:  J Clin Microbiol       Date:  1998-01       Impact factor: 5.948

9.  RifR mutations in the beginning of the Escherichia coli rpoB gene.

Authors:  K Severinov; M Soushko; A Goldfarb; V Nikiforov
Journal:  Mol Gen Genet       Date:  1994-07-25

10.  Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis.

Authors:  D L Williams; L Spring; L Collins; L P Miller; L B Heifets; P R Gangadharam; T P Gillis
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191
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  50 in total

1.  Mutations at four distinct regions of the rpoB gene can reduce the susceptibility of Helicobacter pylori to rifamycins.

Authors:  M Heep; S Odenbreit; D Beck; J Decker; E Prohaska; U Rieger; N Lehn
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

Review 2.  Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective.

Authors:  Stephen H Gillespie
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

3.  Molecular characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Hungary by DNA sequencing and the line probe assay.

Authors:  Z Bártfai; A Somoskövi; C Ködmön; N Szabó; E Puskás; L Kosztolányi; E Faragó; J Mester; L M Parsons; M Salfinger
Journal:  J Clin Microbiol       Date:  2001-10       Impact factor: 5.948

4.  Characterization of rpoB mutations in rifampin-resistant clinical isolates of Mycobacterium tuberculosis from Turkey by DNA sequencing and line probe assay.

Authors:  Cengiz Cavusoglu; Suleyha Hilmioglu; Sevinc Guneri; Altinay Bilgic
Journal:  J Clin Microbiol       Date:  2002-12       Impact factor: 5.948

5.  The beginning of the rpoB gene in addition to the rifampin resistance determination region might be needed for identifying rifampin/rifabutin cross-resistance in multidrug-resistant Mycobacterium tuberculosis isolates from Southern China.

Authors:  Yaoju Tan; Zuqiong Hu; Yanlin Zhao; Xingshan Cai; Chunming Luo; Cairong Zou; Xin Liu
Journal:  J Clin Microbiol       Date:  2011-11-09       Impact factor: 5.948

6.  Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from China.

Authors:  Jun Yue; Wei Shi; Jingping Xie; Yao Li; Erliang Zeng; Honghai Wang
Journal:  J Clin Microbiol       Date:  2003-05       Impact factor: 5.948

7.  Use of molecular methods to identify the Mycobacterium tuberculosis complex (MTBC) and other mycobacterial species and to detect rifampin resistance in MTBC isolates following growth detection with the BACTEC MGIT 960 system.

Authors:  Akos Somoskovi; Qunfeng Song; Judit Mester; Charise Tanner; Yvonne M Hale; Linda M Parsons; Max Salfinger
Journal:  J Clin Microbiol       Date:  2003-07       Impact factor: 5.948

Review 8.  H pylori antibiotic resistance: prevalence, importance, and advances in testing.

Authors:  F Mégraud
Journal:  Gut       Date:  2004-09       Impact factor: 23.059

9.  Molecular detection of rifabutin-susceptible Mycobacterium tuberculosis.

Authors:  Huang-Yao Chen; Ming-Chih Yu; Wei-Lun Huang; Mei-Hua Wu; Yung-Lin Chang; Chien-Rai Che; Ruwen Jou
Journal:  J Clin Microbiol       Date:  2012-03-21       Impact factor: 5.948

10.  First evaluation of an improved assay for molecular genetic detection of tuberculosis as well as rifampin and isoniazid resistances.

Authors:  Valeriu Crudu; Ecaterina Stratan; Elena Romancenco; Vera Allerheiligen; Andreas Hillemann; Nicolae Moraru
Journal:  J Clin Microbiol       Date:  2012-02-01       Impact factor: 5.948
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