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Literature DB >> 10817737

Mutations at four distinct regions of the rpoB gene can reduce the susceptibility of Helicobacter pylori to rifamycins.

M Heep¹, S Odenbreit, D Beck, J Decker, E Prohaska, U Rieger, N Lehn.

Abstract

The transformation of a panel of rpoB mutations (codons 525 to 586) from rifampin-resistant donor strains into Helicobacter pylori 2802A confirmed the MICs associated with the respective mutations. RpoB V149X random mutations were generated and induced different levels of resistance, depending on the replacement amino acid. Mutagenesis of the rpoB gene at codon position 701 (R701H) induced low-level resistance.

Entities: Chemical Mutation Species

Mesh：

Substances：

Year: 2000 PMID： 10817737 PMCID： PMC89941 DOI： 10.1128/AAC.44.6.1713-1715.2000

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

1. Rifampin and rifabutin resistance mechanism in Helicobacter pylori.

Authors: M Heep; D Beck; E Bayerdörffer; N Lehn
Journal: Antimicrob Agents Chemother Date: 1999-06 Impact factor: 5.191

2. In vitro anti-Helicobacter pylori activities of new rifamycin derivatives, KRM-1648 and KRM-1657.

Authors: J K Akada; M Shirai; K Fujii; K Okita; T Nakazawa
Journal: Antimicrob Agents Chemother Date: 1999-05 Impact factor: 5.191

3. The complete genome sequence of the gastric pathogen Helicobacter pylori.

Authors: J F Tomb; O White; A R Kerlavage; R A Clayton; G G Sutton; R D Fleischmann; K A Ketchum; H P Klenk; S Gill; B A Dougherty; K Nelson; J Quackenbush; L Zhou; E F Kirkness; S Peterson; B Loftus; D Richardson; R Dodson; H G Khalak; A Glodek; K McKenney; L M Fitzegerald; N Lee; M D Adams; E K Hickey; D E Berg; J D Gocayne; T R Utterback; J D Peterson; J M Kelley; M D Cotton; J M Weidman; C Fujii; C Bowman; L Watthey; E Wallin; W S Hayes; M Borodovsky; P D Karp; H O Smith; C M Fraser; J C Venter
Journal: Nature Date: 1997-08-07 Impact factor: 49.962

4. Relationship between rifampin MICs for and rpoB mutations of Mycobacterium tuberculosis strains isolated in Japan.

Authors: H Ohno; H Koga; S Kohno; T Tashiro; K Hara
Journal: Antimicrob Agents Chemother Date: 1996-04 Impact factor: 5.191

5. Isolation of rifampin-resistant mutants of Listeria monocytogenes and their characterization by rpoB gene sequencing, temperature sensitivity for growth, and interaction with an epithelial cell line.

Authors: R Morse; K O'Hanlon; M Virji; M D Collins
Journal: J Clin Microbiol Date: 1999-09 Impact factor: 5.948

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Authors: C M Kunin
Journal: Clin Infect Dis Date: 1996-04 Impact factor: 9.079

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Authors: D J Jin; C A Gross
Journal: J Mol Biol Date: 1988-07-05 Impact factor: 5.469

Review 8. Antimicrobial agent resistance in mycobacteria: molecular genetic insights.

Authors: J M Musser
Journal: Clin Microbiol Rev Date: 1995-10 Impact factor: 26.132

9. Mutation to rifampicin resistance at the beginning of the RNA polymerase beta subunit gene in Escherichia coli.

Authors: N A Lisitsyn; E D Sverdlov; E P Moiseyeva; O N Danilevskaya; V G Nikiforov
Journal: Mol Gen Genet Date: 1984

10. Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase.

Authors: K Severinov; M Soushko; A Goldfarb; V Nikiforov
Journal: J Biol Chem Date: 1993-07-15 Impact factor: 5.157

13 in total

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Journal: Antimicrob Agents Chemother Date: 2001-07 Impact factor: 5.191

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Authors: Josephine Kang; Shuyan Huang; Martin J Blaser
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3. Who's Winning the War? Molecular Mechanisms of Antibiotic Resistance in Helicobacter pylori.

Authors: Kathleen R Jones; Jeong-Heon Cha; D Scott Merrell
Journal: Curr Drug ther Date: 2008-09-01

4. Molecular analysis of rifampin resistance in Bacillus anthracis and Bacillus cereus.

Authors: Amy J Vogler; Joseph D Busch; Stephanie Percy-Fine; Christine Tipton-Hunton; Kimothy L Smith; Paul Keim
Journal: Antimicrob Agents Chemother Date: 2002-02 Impact factor: 5.191

5. Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates.

Authors: M Heep; B Brandstätter; U Rieger; N Lehn; E Richter; S Rüsch-Gerdes; S Niemann
Journal: J Clin Microbiol Date: 2001-01 Impact factor: 5.948