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Literature DB >> 6383208

Aztreonam concentrations in human prostatic tissue.

Abstract

The concentrations of aztreonam in human prostatic tissue specimens obtained by transurethral resection were measured in nine patients after the intramuscular administration of a single 1-g dose. The average concentration of aztreonam was 7.8 microgram/g of prostate between 50 and 180 min after dosage. The average ratio of the drug concentration in prostate to that in serum was 0.25. The concentrations of aztreonam achieved were significantly higher than the MICs for most members of the family Enterobacteriaceae implicated in chronic prostatitis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1984 PMID： 6383208 PMCID： PMC179908 DOI： 10.1128/AAC.26.1.20

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

3 in total

1. The concentration of sulphamethoxazole and trimethoprim in human prostate gland.

Authors: W Oosterlinck; R Defoort; G Renders
Journal: Br J Urol Date: 1975-06

2. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.

Authors: R B Sykes; D P Bonner; K Bush; N H Georgopapadakou
Journal: Antimicrob Agents Chemother Date: 1982-01 Impact factor: 5.191

3. Single-dose pharmacokinetics of the monobactam azthreonam (SQ 26,776) in healthy subjects.

Authors: E A Swabb; A A Sugerman; T B Platt; F G Pilkiewicz; M Frantz
Journal: Antimicrob Agents Chemother Date: 1982-06 Impact factor: 5.191

3 in total

6 in total

Aztreonam concentrations in human prostatic tissue.

1. The concentration of sulphamethoxazole and trimethoprim in human prostate gland.

2. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.

3. Single-dose pharmacokinetics of the monobactam azthreonam (SQ 26,776) in healthy subjects.

Review 1. Clinical pharmacokinetics of aztreonam. An update.

Review 2. Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Review 3. Clinical pharmacokinetics of aztreonam.

4. Aztreonam concentrations in human tissues obtained during thoracic and gynecologic surgery.

5. Aztreonam penetration into synovial fluid and bone.

6. Aztreonam concentration in abdominal tissues and bile.