Heart transplant rejection monitored by signal-averaged electrocardiography in patients receiving cyclosporine.

Data from standard and high-frequency signal-averaged electrocardiograms (ECGs) were correlated with the results of 67 endomyocardial biopsies performed in 20 cyclosporine-treated heart transplant recipients. Eight patients (group 1) were in the early postoperative hospitalization period and 12 patients (group 2) were studied after their hospital discharge. The biopsy samples were classified as normal or as indicating early (cellular infiltrate) or definite rejection (myocyte necrosis). The standard ECG parameter studied was the summated QRS voltage in leads I, II, III, V1, and V6. The signal-averaged ECG was evaluated for QRS duration, high-frequency voltage amplitude of the total QRS complex and of its three thirds, peak QRS voltage amplitude, and QRS integrated voltage-time product. The ECG recording obtained at the time of a first normal biopsy sample was considered the normal reference to which additional tracings from the same patient were compared. At the time of subsequent biopsies, the standard ECG parameter showed poor reproducibility (r = .58) and it was inadequate in defining rejection episodes in the early or late postoperative period. The signal-averaged ECG was more reproducible (r = .83) and more accurate in detecting definite rejection during the late posttransplant period than the standard ECG. In group 2 patients, 92% of abnormal signal-averaged ECG recordings were associated with rejection episodes and only 13% of normal tracings were associated with definite rejection. The method was inadequate, however, in monitoring patients during the early postoperative period and in detecting mild forms of rejection in the late postoperative phase.(ABSTRACT TRUNCATED AT 250 WORDS)