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Literature DB >> 6357789

Experimental animal model of surgical wound infection applicable to antibiotic prophylaxis.

F Moesgaard, M C Lykkegaard Nielsen, T Justesen.

Abstract

Wound infection, defined as accumulation of pus draining spontaneously or after opening of the wound, developed in 19 out of 22 guinea pigs (86%) after intraincisional contamination with 10(7) Escherichia coli plus 10(8) Bacteroides fragilis before wound closure. Antibiotic prophylaxis with gentamicin plus clindamycin significantly reduced the wound sepsis rate from 86% to 29% (p less than 0,001). Pus for bacteriological studies was available in all cases of wound infection but one, and culture always revealed both Escherichia coli and Bacteroides fragilis. The animal model presented employs widely accepted criteria for wound infection, and avoids culture of tissue homogenates.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1983 PMID： 6357789 DOI： 10.1007/bf02013904

Source DB: PubMed Journal: Eur J Clin Microbiol ISSN： 0722-2211 Impact factor: 3.267

16 in total

1. The value and duration of defence reactions of the skin to the primary lodgement of bacteria.

Authors: A A MILES; E M MILES; J BURKE
Journal: Br J Exp Pathol Date: 1957-02

2. Septic complications in colo-rectal surgery after 24 hours versus 60 hours of preoperative antibiotic bowel preparation. II. Significance of bacterial concentrations in the bowel for contamination of the operation field and subsequent wound infection.

Authors: J H Scheibel; M Lykkegaard Nielsen; T Wamberg
Journal: Acta Chir Scand Date: 1978

3. Anaerobic infections in chronic prostatitis and chronic urethritis.

Authors: T Justesen; M L Nielsen; T Hattel
Journal: Med Microbiol Immunol Date: 1973-03-08 Impact factor: 3.402

4. An experimental study of the relationship between synergistic wound sepsis and suture materials.

Authors: D McGeehan; D Hunt; A Chaudhuri; P Rutter
Journal: Br J Surg Date: 1980-09 Impact factor: 6.939

5. Bacterial adherence to surgical sutures. A possible factor in suture induced infection.

Authors: S Katz; M Izhar; D Mirelman
Journal: Ann Surg Date: 1981-07 Impact factor: 12.969

6. Prophylactic peroperative intravenous metronidazole in elective colorectal surgery.

Authors: S J Eykyn; B T Jackson; H E Lockhart-Mummery; I Phillips
Journal: Lancet Date: 1979-10-13 Impact factor: 79.321

7. Tinidazole in the prevention of wound infection after elective colorectal surgery.

Authors: P S Hunt; J K Francis; G Peck; K Farrell; A Sali
Journal: Med J Aust Date: 1979-02-24 Impact factor: 7.738

8. Prophylaxis with doxycycline (Vibramycin) in colorectal surgery.

Authors: J Wetterfors; H Hoejer
Journal: Scand J Gastroenterol Suppl Date: 1980

9. The quantitative and histological demonstration of pathogenic synergy between Escherichia coli and Bacteroides fragilis in guinea-pig wounds.

Authors: M J Kelly
Journal: J Med Microbiol Date: 1978-11 Impact factor: 2.472

Experimental animal model of surgical wound infection applicable to antibiotic prophylaxis.

1. The value and duration of defence reactions of the skin to the primary lodgement of bacteria.

2. Septic complications in colo-rectal surgery after 24 hours versus 60 hours of preoperative antibiotic bowel preparation. II. Significance of bacterial concentrations in the bowel for contamination of the operation field and subsequent wound infection.

3. Anaerobic infections in chronic prostatitis and chronic urethritis.

4. An experimental study of the relationship between synergistic wound sepsis and suture materials.

5. Bacterial adherence to surgical sutures. A possible factor in suture induced infection.

6. Prophylactic peroperative intravenous metronidazole in elective colorectal surgery.

7. Tinidazole in the prevention of wound infection after elective colorectal surgery.

8. Prophylaxis with doxycycline (Vibramycin) in colorectal surgery.

9. The quantitative and histological demonstration of pathogenic synergy between Escherichia coli and Bacteroides fragilis in guinea-pig wounds.

10. Cephaloridine prophylaxis in resection of the large intestine.

1. Reduction of experimental wound infection rate by administration of clindamycin in addition to netilmicin.

Review 2. Animal models of external traumatic wound infections.

3. Wound infection rates after intraincisional plus systemic antibiotic prophylaxis in an animal model.

4. Wound infection rates following preoperative versus intraoperative commencement of antibiotic prophylaxis.