Literature DB >> 6396091

Wound infection rates after intraincisional plus systemic antibiotic prophylaxis in an animal model.

F Moesgaard, M C Lykkegaard Nielsen, T Justesen.   

Abstract

The effect of intraincisional application of antibiotics in addition to systemic antibiotic prophylaxis was evaluated in a randomized blind study using a guinea pig model of surgical wound infection. Wounds were contaminated with 10(7) Escherichia coli plus 10(8) Bacteroides fragilis. Wound infection was defined as accumulation of pus draining spontaneously or after opening the wound. Systemic antibiotic prophylaxis with gentamicin plus clindamycin significantly reduced the wound sepsis rate from 83% in the control group to 20% in the treated group (p less than 0.001). Intraincisional application of antibiotics in addition to systemic prophylaxis did not further reduce the rate of wound sepsis (p greater than 0.8).

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Year:  1984        PMID： 6396091     DOI： 10.1007/BF02013614

Source DB:  PubMed          Journal:  Eur J Clin Microbiol        ISSN： 0722-2211            Impact factor:   3.267


  26 in total

1.  The virulence of Staphylococcus pyogenes for man; a study of the problems of wound infection.

Authors:  S D ELEK; P E CONEN
Journal:  Br J Exp Pathol       Date:  1957-12

2.  Physical and chemical configuration of sutures in the development of surgical infection.

Authors:  R F Edlich; P H Panek; G T Rodeheaver; V G Turnbull; L D Kurtz; M T Edgerton
Journal:  Ann Surg       Date:  1973-06       Impact factor: 12.969

3.  The use of topical antibiotics in the prevention of experimental wound infection.

Authors:  W B Hopson; L Britt; R T Sherman; C P Ledes
Journal:  J Surg Res       Date:  1968-06       Impact factor: 2.192

4.  Suture resistance to infection.

Authors:  W V Sharp; T A Belden; P H King; P C Teague
Journal:  Surgery       Date:  1982-01       Impact factor: 3.982

5.  Wound infection rates following preoperative versus intraoperative commencement of antibiotic prophylaxis.

Authors:  F Moesgaard; M C Lykkegaard Nielsen; T Justesen; J H Scheibel
Journal:  Eur J Clin Microbiol       Date:  1984-06       Impact factor: 3.267

6.  Tinidazole in the prevention of wound infection after elective colorectal surgery.

Authors:  P S Hunt; J K Francis; G Peck; K Farrell; A Sali
Journal:  Med J Aust       Date:  1979-02-24       Impact factor: 7.738

7.  Prophylactic lincomycin in the prevention of wound infection following appendicectomy: a double blind study.

Authors:  D A Leigh; R Pease; H Henderson; K Simmons; R Russ
Journal:  Br J Surg       Date:  1976-12       Impact factor: 6.939

8.  Intraincisional antibiotics in laparotomy wounds.

Authors:  F Moesgaard; M Lykkegaard-Nielsen; T Justesen
Journal:  Dis Colon Rectum       Date:  1984-03       Impact factor: 4.585

9.  Single and multiple dose cotrimoxazole and metronidazole in colorectal surgery.

Authors:  A F Higgins; A Lewis; P Noone; M L Hole
Journal:  Br J Surg       Date:  1980-02       Impact factor: 6.939

10.  Cephaloridine prophylaxis in resection of the large intestine.

Authors:  E S Hughes; F T McDermott; A White; J P Masterton
Journal:  Aust N Z J Surg       Date:  1979-08
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  1 in total

1.  A randomized trial of one versus three doses of Augmentin as wound prophylaxis in at-risk abdominal surgery.

Authors:  T Bates; J V Roberts; K Smith; K A German
Journal:  Postgrad Med J       Date:  1992-10       Impact factor: 2.401
  1 in total

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