Literature DB >> 6356243

Regulatory history and experimental support of uncertainty (safety) factors.

M L Dourson, J F Stara.   

Abstract

A synthesis of available literature on uncertainty (safety) factors which are used to estimate acceptable daily intakes (ADIs) for toxicants is presented. This synthesis reveals reasonable qualitative biological premises, as well as specific biological data that support both the use and choice of these factors. A suggestion is made in order to derive a range of ADI. Research needs in various areas of uncertainty are also identified.

Mesh：

Year:  1983        PMID： 6356243     DOI： 10.1016/0273-2300(83)90030-2

Source DB:  PubMed          Journal:  Regul Toxicol Pharmacol        ISSN： 0273-2300            Impact factor:   3.271


  25 in total

1.  Changing the Risk Paradigms Can be Good for Our Health: J-Shaped, Linear and Threshold Dose-Response Models.

Authors:  P F Ricci; S R Straja; A L Cox
Journal:  Dose Response       Date:  2011-09-29       Impact factor: 2.658

2.  Residential releases of number 2 fuel oil: a contributor to indoor air pollution.

Authors:  M B Kaplan; P Brandt-Rauf; J W Axley; T T Shen; G H Sewell
Journal:  Am J Public Health       Date:  1993-01       Impact factor: 9.308

3.  Methods for evaluating variability in human health dose-response characterization.

Authors:  Daniel A Axelrad; R Woodrow Setzer; Thomas F Bateson; Michael DeVito; Rebecca C Dzubow; Julie W Fitzpatrick; Alicia M Frame; Karen A Hogan; Keith Houck; Michael Stewart
Journal:  Hum Ecol Risk Assess       Date:  2019-11-06       Impact factor: 5.190

Review 4.  Use of anatomical and kinetic models in the evaluation of human food additive safety.

Authors:  William L Roth
Journal:  AAPS J       Date:  2005-09-22       Impact factor: 4.009

Review 5.  Model systems and organisms for addressing inter- and intra-species variability in risk assessment.

Authors:  Ivan Rusyn; Weihsueh A Chiu; Fred A Wright
Journal:  Regul Toxicol Pharmacol       Date:  2022-05-28       Impact factor: 3.598

Review 6.  Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span.

Authors:  Stephen Richard Spindler
Journal:  Age (Dordr)       Date:  2011-03-22

7.  Modeling the Human Kinetic Adjustment Factor for Inhaled Volatile Organic Chemicals: Whole Population Approach versus Distinct Subpopulation Approach.

Authors:  M Valcke; A Nong; K Krishnan
Journal:  J Toxicol       Date:  2012-03-07

8.  Medical Device Industry Approaches for Addressing Sources of Failing Cytotoxicity Scores.

Authors:  Helin Räägel; Audrey Turley; Trevor Fish; Jeralyn Franson; Thor Rollins; Sarah Campbell; Matthew R Jorgensen
Journal:  Biomed Instrum Technol       Date:  2021-05-01

9.  Determination of no-observed effect level (NOEL)-biomarker equivalents to interpret biomonitoring data for organophosphorus pesticides in children.

Authors:  Mathieu Valcke; Michèle Bouchard
Journal:  Environ Health       Date:  2009-02-19       Impact factor: 5.984

Review 10.  Comparative biology of test species.

Authors:  E J Calabrese
Journal:  Environ Health Perspect       Date:  1988-04       Impact factor: 9.031
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