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Literature DB >> 6354923

II. IgM-mediated enhancement: dependency on antigen dose, T-cell requirement and lack of evidence for an idiotype-related mechanism.

P Lehner, P Hutchings, P M Lydyard, A Cooke.

Abstract

Passive administration of monoclonal IgM anti-sheep red blood cell antibody 2 hr prior to a low dose of sheep red blood cells (SRBC) markedly enhances the specific antibody response. This IgM enhancement of the response to SRBC is highly reproducible and can furthermore be demonstrated in vitro. The time course and dose dependency of the response indicate that a critical antibody: antigen ratio is necessary for enhancement to occur. The IgM enhancement phenomenon has been demonstrated in several strains of mice, providing strong evidence against an idiotype-related mechanism.

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Year: 1983 PMID： 6354923 PMCID： PMC1454267

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

11 in total

1. Functional characterization of mouse T lymphocytes with IgM-Fc receptors. I. Studies on ADCC and helper cell function.

Authors: B Andersson; A C Skoglund; A Rosen
Journal: J Immunol Date: 1979-11 Impact factor: 5.422

2. Further improvements in the plaque technique for detecting single antibody-forming cells.

Authors: A J Cunningham; A Szenberg
Journal: Immunology Date: 1968-04 Impact factor: 7.397

3. Synergy between IgG and monoclonal IgM antibodies in antibody-dependent cell cytotoxicity.

Authors: L Shen; P M Lydyard; I M Roitt; M W Fanger
Journal: J Immunol Date: 1981-07 Impact factor: 5.422

Review 4. Functional aspects of IgM and IgG Fc receptors on murine T lymphocytes.

Authors: B Andersson; A C Skoglund; M Rönnholm; T Lindsten; E W Lamon; E W Collisson; A S Walia
Journal: Immunol Rev Date: 1981 Impact factor: 12.988

5. IgM antibodies induce the production of antibodies of the same specificity.

Authors: L Forni; A Coutinho; G Köhler; N K Jerne
Journal: Proc Natl Acad Sci U S A Date: 1980-02 Impact factor: 11.205

6. The enhancement of antibody response by IgM antibodies is dependent on antigen-specific T helper cells.

Authors: A Coutinho; L Forni
Journal: Immunobiology Date: 1981 Impact factor: 3.144

7. Competition of 19S and 7S antigen receptors in the regulation of the primary immune response.

Authors: C Henry; N K Jerne
Journal: J Exp Med Date: 1968-07-01 Impact factor: 14.307

8. Regulation of the immune response. I. Reduction in ability of specific antibody to inhibit long-lasting IgG immunological priming after removal of the Fc fragment.

Authors: R Nicholas; S C Sinclair
Journal: J Exp Med Date: 1969-06-01 Impact factor: 14.307

9. Antigen-dependent IgM-mediated enhancement of the sheep erythrocyte response in mice. Evidence for induction of B cells with specificities other than that of the injected antibodies.

Authors: B Heyman; G Andrighetto; H Wigzell
Journal: J Exp Med Date: 1982-04-01 Impact factor: 14.307

10. Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.

Authors: L Moretta; S R Webb; C E Grossi; P M Lydyard; M D Cooper
Journal: J Exp Med Date: 1977-07-01 Impact factor: 14.307

6 in total

II. IgM-mediated enhancement: dependency on antigen dose, T-cell requirement and lack of evidence for an idiotype-related mechanism.

1. Functional characterization of mouse T lymphocytes with IgM-Fc receptors. I. Studies on ADCC and helper cell function.

2. Further improvements in the plaque technique for detecting single antibody-forming cells.

3. Synergy between IgG and monoclonal IgM antibodies in antibody-dependent cell cytotoxicity.

Review 4. Functional aspects of IgM and IgG Fc receptors on murine T lymphocytes.

5. IgM antibodies induce the production of antibodies of the same specificity.

6. The enhancement of antibody response by IgM antibodies is dependent on antigen-specific T helper cells.

7. Competition of 19S and 7S antigen receptors in the regulation of the primary immune response.

8. Regulation of the immune response. I. Reduction in ability of specific antibody to inhibit long-lasting IgG immunological priming after removal of the Fc fragment.

9. Antigen-dependent IgM-mediated enhancement of the sheep erythrocyte response in mice. Evidence for induction of B cells with specificities other than that of the injected antibodies.

10. Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.

Review 1. Natural serum IgM maintains immunological homeostasis and prevents autoimmunity.

2. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response.

3. Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion.

4. Presentation by peritoneal macrophages: modulation by antibody-antigen complexes.

5. Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells.

6. Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytes.