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Literature DB >> 3486817

Presentation by peritoneal macrophages: modulation by antibody-antigen complexes.

Abstract

The effects of immune complex formation on presentation was studied. Immune complexes between an IgG2a monoclonal anti-DNP antibody and TNP-KLH were produced, and the presentation of the carrier molecule by peritoneal macrophages to KLH-primed T cells was monitored. Complex formation was found to enhance the proliferative response of the T cells. This enhancement was specific, was not mediated by lymphokine release, and required antibody with an intact Fc portion. The significance of these results in terms of immune regulation and antigen presentation is discussed.

Mesh：

Substances：

Year: 1986 PMID： 3486817 PMCID： PMC1452616

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

18 in total

1. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors: F C GREENWOOD; W M HUNTER; J S GLOVER
Journal: Biochem J Date: 1963-10 Impact factor: 3.857

2. Antigen-induced proliferation of guinea pig lymphocytes in vitro: obligatory role of macrophages in the recognition of antigen by immune T-lymphocytes.

Authors: J A Waldron; R G Horn; A S Rosenthal
Journal: J Immunol Date: 1973-07 Impact factor: 5.422

3. B cells as antigen-presenting cells: the requirement for B cell activation.

Authors: T Kakiuchi; R W Chesnut; H M Grey
Journal: J Immunol Date: 1983-07 Impact factor: 5.422

4. II. IgM-mediated enhancement: dependency on antigen dose, T-cell requirement and lack of evidence for an idiotype-related mechanism.

Authors: P Lehner; P Hutchings; P M Lydyard; A Cooke
Journal: Immunology Date: 1983-11 Impact factor: 7.397

5. Antigen presentation by normal B cells, B cell tumors, and macrophages: functional and biochemical comparison.

Authors: R W Chesnut; S M Colon; H M Grey
Journal: J Immunol Date: 1982-04 Impact factor: 5.422

6. Studies on the capacity of B cells to serve as antigen-presenting cells.

Authors: R W Chesnut; H M Grey
Journal: J Immunol Date: 1981-03 Impact factor: 5.422

Review 7. The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages.

Authors: E R Unanue
Journal: Adv Immunol Date: 1981 Impact factor: 3.543

Review 3. Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses.

Authors: Claus H Nielsen; Klaus Bendtzen
Journal: Adv Exp Med Biol Date: 2012 Impact factor: 2.622

3 in total

Presentation by peritoneal macrophages: modulation by antibody-antigen complexes.

1. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

2. Antigen-induced proliferation of guinea pig lymphocytes in vitro: obligatory role of macrophages in the recognition of antigen by immune T-lymphocytes.

3. B cells as antigen-presenting cells: the requirement for B cell activation.

4. II. IgM-mediated enhancement: dependency on antigen dose, T-cell requirement and lack of evidence for an idiotype-related mechanism.

5. Antigen presentation by normal B cells, B cell tumors, and macrophages: functional and biochemical comparison.

6. Studies on the capacity of B cells to serve as antigen-presenting cells.

Review 7. The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages.

8. Prostaglandin synthesis by macrophages requires a specific receptor-ligand interaction.

9. Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

10. Internalization and degradation of macrophage Fc receptors bound to polyvalent immune complexes.

1. Immunization procedures for E. coli proteins.

2. Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A).

Review 3. Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses.