Literature DB >> 6352333

Does the lactose carrier of Escherichia coli function as a monomer?

J K Wright, U Weigel, A Lustig, H Bocklage, M Mieschendahl, B Müller-Hill, P Overath.   

Abstract

The purified lactose carrier of Escherichia coli (product of the lac Y gene) is shown to be a monomer in detergent micelles of dodecyl-O-beta-D-maltoside. The negative-dominant phenotype of mutant carriers (lacY-d mutants) could not be verified by measurements of the rate of galactoside transport in lacY+/Y-d diploid strains. It is proposed that the membrane-embedded carrier functions as a monomer in galactoside-H+ symport.

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Year:  1983        PMID： 6352333     DOI： 10.1016/0014-5793(83)81039-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Functional complementation of internal deletion mutants in the lactose permease of Escherichia coli.

Authors:  E Bibi; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

2.  Reconstitution of an active lactose carrier in vivo by simultaneous synthesis of two complementary protein fragments.

Authors:  W Wrubel; U Stochaj; U Sonnewald; C Theres; R Ehring
Journal:  J Bacteriol       Date:  1990-09       Impact factor: 3.490

3.  Surface-exposed positions in the transmembrane helices of the lactose permease of Escherichia coli determined by intermolecular thiol cross-linking.

Authors:  Lan Guan; Franklin D Murphy; H Ronald Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

4.  A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose.

Authors:  M Markgraf; H Bocklage; B Müller-Hill
Journal:  Mol Gen Genet       Date:  1985

5.  Structural features of the uniporter/symporter/antiporter superfamily.

Authors:  V C Goswitz; R J Brooker
Journal:  Protein Sci       Date:  1995-03       Impact factor: 6.725

Review 6.  Anion-exchange mechanisms in bacteria.

Authors:  P C Maloney; S V Ambudkar; V Anatharam; L A Sonna; A Varadhachary
Journal:  Microbiol Rev       Date:  1990-03

7.  Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli.

Authors:  M Sahin-Tóth; M C Lawrence; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

8.  Lactose permease of Escherichia coli: properties of mutants defective in substrate translocation.

Authors:  P Overath; U Weigel; J M Neuhaus; J Soppa; R Seckler; I Riede; H Bocklage; B Müller-Hill; G Aichele; J K Wright
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

9.  TetL tetracycline efflux protein from Bacillus subtilis is a dimer in the membrane and in detergent solution.

Authors:  Markus Safferling; Heather Griffith; Jie Jin; Josh Sharp; Magdia De Jesus; Caroline Ng; Terry A Krulwich; Da-Neng Wang
Journal:  Biochemistry       Date:  2003-12-02       Impact factor: 3.162

10.  The structure of the lactose permease derived from Raman spectroscopy and prediction methods.

Authors:  H Vogel; J K Wright; F Jähnig
Journal:  EMBO J       Date:  1985-12-16       Impact factor: 11.598
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