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Literature DB >> 6336943

Human hybridomas from patients with malignant disease.

K Sikora, T Alderson, J Ellis, J Phillips, J Watson.

Abstract

Lymphocytes from 180 patients with a variety of malignant diseases were collected and fused with a human myeloma-derived line, LON-LICR-HMy2/CAM1. A total of 162 hybridomas was obtained. Only B lymphocyte markers were found on the surface of the fusion products. Flow cytometric analysis revealed a stably increased DNA content in the hybridoma cells. Some hybridoma supernatants were found to contain new Ig chains. Anti-tumour binding activity was found in 12 supernatants.

Entities: Disease Species

Mesh：

Substances：

Year: 1983 PMID： 6336943 PMCID： PMC2011244 DOI： 10.1038/bjc.1983.16

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

20 in total

1. Mouse-human hybridomas. The conversion of non-secreting human B cells into Ig secretors.

Authors: R Levy; J Dilley; K Sikora; R Kucherlapati
Journal: Curr Top Microbiol Immunol Date: 1978 Impact factor: 4.291

2. Specific antigen in serum of patients with colon carcinoma.

Authors: H Koprowski; M Herlyn; Z Steplewski; H F Sears
Journal: Science Date: 1981-04-03 Impact factor: 47.728

3. Production of human hybridomas secreting antibodies to measles virus.

Authors: C M Croce; A Linnenbach; W Hall; Z Steplewski; H Koprowski
Journal: Nature Date: 1980-12-04 Impact factor: 49.962

4. Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.

Authors: L Olsson; H S Kaplan
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

5. Human monoclonal antibody against Forssman antigen.

Authors: R Nowinski; C Berglund; J Lane; M Lostrom; I Bernstein; W Young; S I Hakomori; L Hill; M Cooney
Journal: Science Date: 1980-10-31 Impact factor: 47.728

6. A procedure for the fusion of cells in suspension by means of polyethylene glycol.

Authors: A Hales
Journal: Somatic Cell Genet Date: 1977-03

7. Pattern of immunoglobulin synthesis and assembly in a human-mouse somatic cell hybrid clone.

Authors: J Schwaber; E P Cohen
Journal: Proc Natl Acad Sci U S A Date: 1974-06 Impact factor: 11.205

8. Pluripotent teratocarcinoma-thymus somatic cell hybrids.

Authors: R A Miller; F H Ruddle
Journal: Cell Date: 1976-09 Impact factor: 41.582

9. Generation of human monoclonal antibodies reactive with human mammary carcinoma cells.

Authors: J Schlom; D Wunderlich; Y A Teramoto
Journal: Proc Natl Acad Sci U S A Date: 1980-11 Impact factor: 11.205

10. Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes.

Authors: N N Iscove; F Melchers
Journal: J Exp Med Date: 1978-03-01 Impact factor: 14.307

18 in total

1. Generating human monoclonal antibodies.

Authors: A M Neville; P A Edwards; M J O'Hare
Journal: Med Oncol Tumor Pharmacother Date: 1984

Review 2. Use of Human Hybridoma Technology To Isolate Human Monoclonal Antibodies.

Authors: Scott A Smith; James E Crowe
Journal: Microbiol Spectr Date: 2015-02

3. Detection of lymphocytes in malignant gliomas by monoclonal antibodies.

Authors: K Yasuda; T Alderson; J Phillips; K Sikora
Journal: J Neurol Neurosurg Psychiatry Date: 1983-08 Impact factor: 10.154

Review 4. Manipulation of host resistance in cancer therapy.

Authors: R W Baldwin
Journal: Springer Semin Immunopathol Date: 1982

Review 5. Antibody-mediated targeting in the treatment and diagnosis of cancer: an overview.

Authors: C H Ford; A G Casson
Journal: Cancer Chemother Pharmacol Date: 1986 Impact factor: 3.333

Review 6. Human monoclonal antibodies.

Authors: S P Cole; B G Campling; T Atlaw; D Kozbor; J C Roder
Journal: Mol Cell Biochem Date: 1984-06 Impact factor: 3.396

10. A monoclonal antibody (Po66) directed against human lung squamous cell carcinoma immunolocalization of tumour xenografts in nude mice.

Authors: L Dazord; D Bourel; A Martin; R Lecorre; P Bourguet; J Bohy; J C Saccavini; P Delaval; M Louvet; L Toujas
Journal: Cancer Immunol Immunother Date: 1987 Impact factor: 6.968