| Literature DB >> 6163212 |
H Koprowski, M Herlyn, Z Steplewski, H F Sears.
Abstract
The binding of monoclonal antibody specific for colon carcinoma was inhibited by serum from patients with adenocarcinoma of the colon but not by serum from patients with other bowel diseases or from healthy volunteers. Of other malignancies studied, serum from two patients with gastric carcinoma and two patients with pancreatic carcinoma also inhibited the specific binding of monoclonal antibody. The levels of carcinoembryonic antigen in these serum samples were not correlated with their levels of binding inhibition. Such monoclonal antibodies may prove useful for the detection of colorectal carcinoma.Entities:
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Year: 1981 PMID： 6163212 DOI： 10.1126/science.6163212
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728