Literature DB >> 6333383

Fine-specificity of the immune response to oxazolones. IV. Furyloxazolone-specific cytolytic T lymphocytes (unlike antibodies) are not heteroclitic.

A Matoso-Ferreira.   

Abstract

Antibodies, raised in CBA and C3H mice, to a hapten 2-furyloxazolone (furyl Ox) have a strange (heteroclitic) fine-specificity, having a higher affinity for the chemical analogue 2-styryloxazolone (styryl Ox) than for furyl Ox. Other mouse strains were found to produce 'normal' anti-furyl Ox antibodies, and the heteroclicity was inherited as an Igh allotype-linked trait (Mäkelä, Matoso-Ferreira & Kaartinen 1983). Hapten-specific cytolytic T lymphocytes (CTL) were generated by painting cyclophosphamide-treated mice with chemically reactive haptens, furyl Ox and styryl Ox, and their fine-specificity was investigated. Cytolytic cells generated in this way were 'homoclitic' in all cases, showing a preference for targets coupled with the homologous haptens (the immunogens).

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Year:  1984        PMID： 6333383      PMCID： PMC1454930     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  16 in total

1.  Micromethods for induction and assay of mouse mixed lymphocyte reactions and cytotoxicity.

Authors:  E Simpson; R Gordon; M Taylor; J Mertin; P Chandler
Journal:  Eur J Immunol       Date:  1976-07       Impact factor: 5.532

2.  Fluorescent labeling of proteins and a plasma membrane using cycloheptaamylose-dansyl chloride complex.

Authors:  T Kinoshita; F Iinuma; A Tsuji
Journal:  Anal Biochem       Date:  1974-10       Impact factor: 3.365

3.  Single lymph node cells producing heteroclitic bacteriophage antibody.

Authors:  O Mäkelä
Journal:  J Immunol       Date:  1965-08       Impact factor: 5.422

4.  A hapten-specific Ir gene.

Authors:  J L Pelkonen; M Kaartinen; K Karjalainen; O Mäkelä
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

5.  Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl.

Authors:  M E Sunday; J Z Weinberger; B Benacerraf; M E Dorf
Journal:  J Immunol       Date:  1980-10       Impact factor: 5.422

6.  Fine specificity of cytotoxic T lymphocytes: C57BL effector cells induced by autologous cells modified with hapten (4-hydroxy-3-nitro-phenyl)acetyl (NIP) are not heteroclitic.

Authors:  I Andó; P Kisielow
Journal:  Eur J Immunol       Date:  1979-03       Impact factor: 5.532

7.  Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds.

Authors:  T G Rehn; J K Inman; G M Shearer
Journal:  J Exp Med       Date:  1976-10-01       Impact factor: 14.307

8.  Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. I. Genetic control of delayed-type hypersensitivity by VH and I-A-region genes.

Authors:  J Z Weinberger; M I Greene; B Benacerraf; M E Dorf
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307

9.  Inheritance of antibody specificity. I. Anti-(4-hydroxy-3-nitrophenyl)acetyl of the mouse primary response.

Authors:  T Imanishi; O Mäkelä
Journal:  J Exp Med       Date:  1974-12-01       Impact factor: 14.307

10.  Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses.

Authors:  M E Sunday; B Benacerraf; M E Dorf
Journal:  J Exp Med       Date:  1980-12-01       Impact factor: 14.307
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