Literature DB >> 62013

Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds.

T G Rehn, J K Inman, G M Shearer.   

Abstract

The specificity of C57BL/10 cytotoxic effector cells generated by in vitro sensitization with autologous spleen cells modified with a series of related nitrophenyl compounds was investigated. The failure of trinitrophenyl (TNP)-sensitized effector cells to lyse TNP-beta-alanylglycylglycyl(AGG)-modified target cells is presented as evidence contradicting the intimacy or dual receptor model or T-cell recognition in its simplest form. Data are also shown indicating that sensitization with N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-AGG-modified stimulating cells generates noncross-reacting clones of cytotoxic effector cells.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 62013      PMCID： PMC2190423          DOI： 10.1084/jem.144.4.1134

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

1.  Coupling of large haptens to proteins and cell surfaces: preparation of stable, optimally sensitized erythrocytes for hapten-specific, hemolytic plaque assays.

Authors:  J K Inman; B Merchant; L Claflin; S E Tacey
Journal:  Immunochemistry       Date:  1973-03

2.  Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.

Authors:  R M Zinkernagel; P C Doherty
Journal:  Nature       Date:  1974-10-11       Impact factor: 49.962

3.  Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.

Authors:  G M Shearer
Journal:  Eur J Immunol       Date:  1974-08       Impact factor: 5.532

4.  Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

Authors:  R M Zinkernagel; P C Doherty
Journal:  Nature       Date:  1974-04-19       Impact factor: 49.962

5.  Cell-medicated cytotoxicity against ectromelia virus-infected target cells. III. Role of the H-2 gene complex.

Authors:  I D Gardner; N A Bowern; R V Blanden
Journal:  Eur J Immunol       Date:  1975-02       Impact factor: 5.532

6.  T cell memory for the cytotoxic response to hapten-modified target cells.

Authors:  H S Koren; J R Wunderlich; J K Inman
Journal:  J Immunol       Date:  1976-02       Impact factor: 5.422

7.  Antigen recognition and the immune response. Humoral and cellular immune responses to small mono- and bifunctional antigen molecules.

Authors:  S S Alkan; E B Williams; D E Nitecki; J W Goodman
Journal:  J Exp Med       Date:  1972-06-01       Impact factor: 14.307

8.  Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.

Authors:  A M Schmitt-Verhulst; D H Sachs; G M Shearer
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307

9.  The specificity of cellular immune responses in guinea pigs. I. T cells specific for 2,4-dinitrophenyl-o-tyrosyl residues.

Authors:  C A Janeway; B E Cohen; S Z Ben-Sasson; W E Paul
Journal:  J Exp Med       Date:  1975-01-01       Impact factor: 14.307

10.  Cell-mediated lympholysis of N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-beta-anaylglycylglycyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by the H-2K and H-2D serological regions of the murine major histocompatibility complex.

Authors:  T G Rehn; G M Shearer; H S Koren; J K Inman
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307
View more
  10 in total

1.  Nature and specificity of effector cells in cell-mediated cytolysis of mouse adenovirus-infected cells.

Authors:  T Inada; H Uetake
Journal:  Infect Immun       Date:  1978-10       Impact factor: 3.441

2.  Fine-specificity of the immune response to oxazolones. IV. Furyloxazolone-specific cytolytic T lymphocytes (unlike antibodies) are not heteroclitic.

Authors:  A Matoso-Ferreira
Journal:  Immunology       Date:  1984-11       Impact factor: 7.397

3.  Specificity of cytotoxic effector cells directed against trinitrobenzene sulfonate-modified syngeneic cells. Failure to recognize cell surface-bound trinitrophenyl dextran.

Authors:  P A Henkart; M Schmitt-Verhulst; G M Shearer
Journal:  J Exp Med       Date:  1977-10-01       Impact factor: 14.307

4.  T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.

Authors:  C A Janeway; P D Murphy; J Kemp; H Wigzell
Journal:  J Exp Med       Date:  1978-04-01       Impact factor: 14.307

5.  Viral specificity of H-2-restricted T killer cells directed against syngeneic tumors induced by Gross, Friend, or Rauscher leukemia virus.

Authors:  F Plata; F Lilly
Journal:  J Exp Med       Date:  1979-11-01       Impact factor: 14.307

6.  Specificity of cytotoxicity T cells directed to influenza virus hemagglutinin.

Authors:  T J Braciale
Journal:  J Exp Med       Date:  1979-04-01       Impact factor: 14.307

7.  Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses.

Authors:  M E Sunday; B Benacerraf; M E Dorf
Journal:  J Exp Med       Date:  1980-12-01       Impact factor: 14.307

8.  Cytotoxic T cells distinguish between trinitrophenyl- and dinitrophenyl-modified syngeneic cells.

Authors:  J Forman
Journal:  J Exp Med       Date:  1977-08-01       Impact factor: 14.307

9.  H-2-restricted cytotoxic effectors generated in vitro by the addition of trinitrophenyl-conjugated soluble proteins.

Authors:  A M Schmitt-Verhulst; C B Pettinelli; P A Henkart; J K Lunney; G M Shearer
Journal:  J Exp Med       Date:  1978-02-01       Impact factor: 14.307

10.  Antibody to influenza virus matrix protein detects a common antigen on the surface of cells infected with type A influenza viruses.

Authors:  W E Biddison; P C Doherty; R G Webster
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.