Literature DB >> 6330003

Immunocytochemical localization of testosterone in human hepatocellular carcinoma.

L Y Wong, S H Chan, C J Oon, A Rauff.   

Abstract

A study of 10 hepatoma patients was carried out for the detection and localization of oestrogen, progesterone, testosterone, and their corresponding binding sites in liver tumour cells using immunoperoxidase and immunofluorescent techniques on histopathological sections and cultured monolayers. None of the hepatomas was positive for progesterone and its receptor; one was positive for oestrogen and its receptor; five were positive for testosterone and its receptor. Oestrogen, testosterone and their respective receptors localized predominantly to the cytoplasm of hepatoma cells. The results obtained in this investigation reveal an association between testosterone and human liver cancer which may be useful in the selection and monitoring of liver cancer patients to future hormonal therapy.

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Year:  1984        PMID： 6330003     DOI： 10.1007/bf01003395

Source DB:  PubMed          Journal:  Histochem J        ISSN： 0018-2214


  14 in total

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Authors:  J HIGGINSON
Journal:  Cancer Res       Date:  1963-11       Impact factor: 12.701

2.  Primary carcinoma of the liver; a clinicopathologic study of one hundred eight cases.

Authors:  R A MACDONALD
Journal:  AMA Arch Intern Med       Date:  1957-02

3.  Influence of sex and sex hormones on development of hepatomas and other hepatic lesions in strain AX C rats ingesting 2-diacetylaminofluorene.

Authors:  H P MORRIS; H I FIRMINGER
Journal:  J Natl Cancer Inst       Date:  1956-02       Impact factor: 13.506

4.  Hepatocellular carcinoma in Great Britain: influence of age, sex, HBsAg status, and aetiology of underlying cirrhosis.

Authors:  P J Johnson; N Krasner; B Portmann; A L Eddleston; R Williams
Journal:  Gut       Date:  1978-11       Impact factor: 23.059

5.  Primary carcinoma of the liver: a study of 282 cases in Ugandan Africans.

Authors:  P P Anthony
Journal:  J Pathol       Date:  1973-05       Impact factor: 7.996

6.  Primary carcinoma of the liver. A study of 121 cases.

Authors:  E G Ohlsson; J G Nordén
Journal:  Acta Pathol Microbiol Scand       Date:  1965

7.  Are histochemical methods for estrogen receptor valid?

Authors:  G C Chamness; W D Mercer; W L McGuire
Journal:  J Histochem Cytochem       Date:  1980-08       Impact factor: 2.479

8.  Hepatocellular carcinoma in young women on oral contraceptives.

Authors:  W M Christopherson; E T Mays; G Barrows
Journal:  Lancet       Date:  1978-07-01       Impact factor: 79.321

9.  Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material.

Authors:  J Burns
Journal:  Histochemistry       Date:  1975-06-05

10.  Immunofluorescent detection of estrogen receptors in breast cancer. Comparison with dextran-coated charcoal and sucrose gradient assays.

Authors:  L P Pertschuk; E H Tobin; D J Brigati; D S Kim; N D Bloom; E Gaetjens; P J Berman; A C Carter; G A Degenshein
Journal:  Cancer       Date:  1978-03       Impact factor: 6.860
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  6 in total

1.  Treatment of primary liver cancer in Singapore. A review of 3200 cases seen between January 1, 1977, and July 31, 1987.

Authors:  C J Oon; A Rauff; L K Tan
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

Review 2.  Influence of sex hormones on pancreatic cancer.

Authors:  A Andrén-Sandberg; J Johansson
Journal:  Int J Pancreatol       Date:  1990 Aug-Nov

3.  Androgen receptor in hepatocellular carcinoma as a prognostic factor after hepatic resection.

Authors:  N Nagasue; Y C Chang; T Hayashi; G Galizia; H Kohno; T Nakamura; H Yukaya
Journal:  Ann Surg       Date:  1989-04       Impact factor: 12.969

4.  Long-term survival following treatment of hepatocellular carcinoma in Singapore: evaluation of Wellferon in the prophylaxis of high-risk pre-cancerous conditions.

Authors:  C J Oon
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 5.  Role of sex steroid receptors in pathobiology of hepatocellular carcinoma.

Authors:  Mamta Kalra; Jary Mayes; Senait Assefa; Anil-K Kaul; Rashmi Kaul
Journal:  World J Gastroenterol       Date:  2008-10-21       Impact factor: 5.742

Review 6.  The androgen receptor as an emerging target in hepatocellular carcinoma.

Authors:  Tatsuo Kanda; Osamu Yokosuka
Journal:  J Hepatocell Carcinoma       Date:  2015-06-26
  6 in total

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