Literature DB >> 6320162

Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.

J Finer-Moore, R M Stroud.   

Abstract

Fourier analysis of the hydrophobicities of the acetylcholine receptor subunit sequences reveals regions of amphipathic secondary structure. Prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function. Knowledge of the three-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints.

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Year:  1984        PMID： 6320162      PMCID： PMC344629          DOI： 10.1073/pnas.81.1.155

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence.

Authors:  M Noda; H Takahashi; T Tanabe; M Toyosato; Y Furutani; T Hirose; M Asai; S Inayama; T Miyata; S Numa
Journal:  Nature       Date:  1982-10-28       Impact factor: 49.962

2.  Structure and function of an acetylcholine receptor.

Authors:  J Kistler; R M Stroud; M W Klymkowsky; R A Lalancette; R H Fairclough
Journal:  Biophys J       Date:  1982-01       Impact factor: 4.033

3.  A simple method for displaying the hydropathic character of a protein.

Authors:  J Kyte; R F Doolittle
Journal:  J Mol Biol       Date:  1982-05-05       Impact factor: 5.469

4.  Structural models of the nicotinic acetylcholine receptor and its toxin-binding sites.

Authors:  H R Guy
Journal:  Cell Mol Neurobiol       Date:  1981-09       Impact factor: 5.046

5.  Acetylcholine receptor: complex of homologous subunits.

Authors:  M A Raftery; M W Hunkapiller; C D Strader; L E Hood
Journal:  Science       Date:  1980-06-27       Impact factor: 47.728

6.  Biochemical properties of acteylcholine receptor subunits from Torpedo californica.

Authors:  J Lindstrom; J Merlie; G Yogeeswaran
Journal:  Biochemistry       Date:  1979-10-16       Impact factor: 3.162

7.  Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain.

Authors:  A Devillers-Thiery; J Giraudat; M Bentaboulet; J P Changeux
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

8.  Inhibition of glycosylation with tunicamycin blocks assembly of newly synthesized acetylcholine receptor subunits in muscle cells.

Authors:  J P Merlie; R Sebbane; S Tzartos; J Lindstrom
Journal:  J Biol Chem       Date:  1982-03-10       Impact factor: 5.157

9.  Acetylcholine receptor channel ionic selectivity: ions experience an aqueous environment.

Authors:  C A Lewis; C F Stevens
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

Review 10.  Mechanisms for the incorporation of proteins in membranes and organelles.

Authors:  D D Sabatini; G Kreibich; T Morimoto; M Adesnik
Journal:  J Cell Biol       Date:  1982-01       Impact factor: 10.539
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  133 in total

Review 1.  Inherited and experimentally induced changes in gating kinetics of muscle nicotinic acetylcholine receptor.

Authors:  C Bouzat; F J Barrantes
Journal:  J Mol Neurosci       Date:  1999 Aug-Oct       Impact factor: 3.444

2.  An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein function.

Authors:  J S Orlando; D A Ornelles
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

3.  Immunological characterization of 5-HT3 receptor transmembrane topology.

Authors:  Avron D Spier; Sarah C R Lummis
Journal:  J Mol Neurosci       Date:  2002-06       Impact factor: 3.444

4.  Protein stability and interaction of the nicotinic acetylcholine receptor with cholinergic ligands studied by Fourier-transform infrared spectroscopy.

Authors:  G Fernandez-Ballester; J Castresana; J L Arrondo; J A Ferragut; J M Gonzalez-Ros
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

Review 5.  Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators.

Authors:  E L Ochoa; A Chattopadhyay; M G McNamee
Journal:  Cell Mol Neurobiol       Date:  1989-06       Impact factor: 5.046

6.  Characterization of regions within the N-terminal 6-kilodalton domain of phytochrome A that modulate its biological activity.

Authors:  E T Jordan; J M Marita; R C Clough; R D Vierstra
Journal:  Plant Physiol       Date:  1997-10       Impact factor: 8.340

7.  Determination of intrinsic hydrophilicity/hydrophobicity of amino acid side chains in peptides in the absence of nearest-neighbor or conformational effects.

Authors:  James M Kovacs; Colin T Mant; Robert S Hodges
Journal:  Biopolymers       Date:  2006       Impact factor: 2.505

8.  Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.

Authors:  B L Kagan; M E Selsted; T Ganz; R I Lehrer
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

9.  Control pathways of the 67 kDa laminin binding protein: surface expression and activity of a new ligand binding domain.

Authors:  T H Landowski; S Uthayakumar; J R Starkey
Journal:  Clin Exp Metastasis       Date:  1995-09       Impact factor: 5.150

10.  CD and DNA binding studies of a proline repeat-containing segment of the replication arrest protein Tus.

Authors:  M L Nedved; P A Gottlieb; G R Moe
Journal:  Nucleic Acids Res       Date:  1994-11-25       Impact factor: 16.971
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