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Literature DB >> 6572962

Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain.

A Devillers-Thiery, J Giraudat, M Bentaboulet, J P Changeux.

Abstract

A 1,350-base-pair-long cDNA clone, named p alpha-2, was isolated by hybridization to the previously characterized clone p alpha-1 and found to be specific for the alpha-subunit of the Torpedo marmorata acetylcholine receptor. The nucleotide sequences of both cDNA inserts were analyzed and the sequence of the complete coding region and part of the 5' and 3' untranslated regions of the alpha-chain mRNA was determined. The complete amino acid sequence of the alpha-chain precursor is presented and used to develop a model for the transmembrane organization of the polypeptide.

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Year: 1983 PMID： 6572962 PMCID： PMC393754 DOI： 10.1073/pnas.80.7.2067

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

31 in total

1. Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence.

Authors: M Noda; H Takahashi; T Tanabe; M Toyosato; Y Furutani; T Hirose; M Asai; S Inayama; T Miyata; S Numa
Journal: Nature Date: 1982-10-28 Impact factor: 49.962

2. The molecular cloning and characterisation of cDNA coding for the alpha subunit of the acetylcholine receptor.

Authors: K Sumikawa; M Houghton; J C Smith; L Bell; B M Richards; E A Barnard
Journal: Nucleic Acids Res Date: 1982-10-11 Impact factor: 16.971

3. Specificity and localization of the acetylcholine receptor kinase.

Authors: C G Davis; A S Gordon; I Diamond
Journal: Proc Natl Acad Sci U S A Date: 1982-06 Impact factor: 11.205

4. Structure and function of an acetylcholine receptor.

Authors: J Kistler; R M Stroud; M W Klymkowsky; R A Lalancette; R H Fairclough
Journal: Biophys J Date: 1982-01 Impact factor: 4.033

5. In vitro synthesis, glycosylation, and membrane insertion of the four subunits of Torpedo acetylcholine receptor.

Authors: D J Anderson; G Blobel
Journal: Proc Natl Acad Sci U S A Date: 1981-09 Impact factor: 11.205

6. Membrane proteins: the amino acid composition of membrane-penetrating segments.

Authors: G von Heijne
Journal: Eur J Biochem Date: 1981-11

7. Reconstitution of a functional acetylcholine receptor. Incorporation into artificial lipid vesicles and pharmacology of the agonist-controlled permeability changes.

Authors: J L Popot; J Cartaud; J P Changeux
Journal: Eur J Biochem Date: 1981-08

8. Molecular cloning of cDNA coding for the gamma subunit of Torpedo acetylcholine receptor.

Authors: M Ballivet; J Patrick; J Lee; S Heinemann
Journal: Proc Natl Acad Sci U S A Date: 1982-07 Impact factor: 11.205

9. Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata.

Authors: R Oswald; J P Changeux
Journal: Proc Natl Acad Sci U S A Date: 1981-06 Impact factor: 11.205

77 in total

Review 1. Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators.

Authors: E L Ochoa; A Chattopadhyay; M G McNamee
Journal: Cell Mol Neurobiol Date: 1989-06 Impact factor: 5.046

Review 2. Intracellular traffic of newly synthesized proteins. Current understanding and future prospects.

Authors: V R Lingappa
Journal: J Clin Invest Date: 1989-03 Impact factor: 14.808

Review 3. Molecular investigations on the nicotinic acetylcholine receptor: conformational mapping and dynamic exploration using photoaffinity labeling.

Authors: F Kotzyba-Hibert; T Grutter; M Goeldner
Journal: Mol Neurobiol Date: 1999-08 Impact factor: 5.590

4. Amino acids bracketing the predicted transmembrane domains of membrane proteins.

Authors: C Pidgeon; R L Williard; S C Schroeder
Journal: Pharm Res Date: 1989-09 Impact factor: 4.200

5. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.

Authors: B L Kagan; M E Selsted; T Ganz; R I Lehrer
Journal: Proc Natl Acad Sci U S A Date: 1990-01 Impact factor: 11.205

6. A molecular model for an acetylcholine binding site: ion channel and the bilayer helices of the acetylcholine receptor assigned using single group rotation theory and electrostatic interactions.

Authors: E M Kosower
Journal: Biophys J Date: 1984-01 Impact factor: 4.033