Literature DB >> 631639

Lymphocytotoxicity test against rabbit hepatocytes in chronic liver diseases.

A Facchini, G F Stefanini, M Bernardi, F Miglio, G Gasbarrini, G Labö.   

Abstract

We have studied the cytotoxicity against rabbit liver cells of lymphocytes from the peripheral blood of 71 patients with various liver diseases. The group with chronic active hepatitis and three patients with acute alcoholic hepatitis showed significantly higher mean values of lymphocytotoxicity (P less than 0.001) compared with the other patients with chronic persistent hepatitis, post-necrotic fibrosis and cirrhosis. Wilson's disease, and prolonged viral hepatitis. The mean cytotoxicity of these last groups did not differ significantly from controls. In four out of six patients with chronic active hepatitis a significant decrease of lymphocytotoxicity was found after immunosuppressive therapy with oral prednisolone. A good correlation between the lymphocytotoxicity test and histological signs of activity suggests that a cell-mediated immune aggression is present in this disease.

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Year:  1978        PMID： 631639      PMCID： PMC1411892          DOI： 10.1136/gut.19.3.189

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  9 in total

1.  Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis.

Authors:  U Hopf; K H Meyer zum Büschenfelde; W Arnold
Journal:  N Engl J Med       Date:  1976-03-11       Impact factor: 91.245

2.  Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis.

Authors:  A D Thomson; M A Cochrane; I G McFarlane; A L Eddleston; R Williams
Journal:  Nature       Date:  1974-12-20       Impact factor: 49.962

3.  An immunofluorescence procedure for the detection of intracellular immunoglobulins.

Authors:  W Hijmans; H R Schuit; F Klein
Journal:  Clin Exp Immunol       Date:  1969-04       Impact factor: 4.330

4.  Inadequate antibody response to hBAg or suppressor T-cell defect in development of active chronic hepatitis.

Authors:  A L Eddleston; R Williams
Journal:  Lancet       Date:  1974-12-28       Impact factor: 79.321

5.  Liver-specific antigens of different species. II. Localization of a membrane antigen at cell surface of isolated hepatocytes.

Authors:  U Hopf; K H Meyer zum Büschenfelde; J Freudenberg
Journal:  Clin Exp Immunol       Date:  1974-01       Impact factor: 4.330

6.  Two immunologic reactions in the pathogenesis of hepatitis?

Authors:  F Paronetto; H Popper
Journal:  N Engl J Med       Date:  1976-03-11       Impact factor: 91.245

7.  Antibody-dependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis.

Authors:  A M Cochrane; A Moussouros; A D Thomsom; A L Eddleston; R Wiiliams
Journal:  Lancet       Date:  1976-02-28       Impact factor: 79.321

8.  Immunological studies in patients with chronic active hepatitis. Cytotoxic activity of lymphocytes to autochthonous liver cells grown in tissue culture.

Authors:  F Paronetto; S Vernace
Journal:  Clin Exp Immunol       Date:  1975-01       Impact factor: 4.330

Review 9.  Alcoholic hepatitis. Cell-mediated immunological response to alcoholic hyalin.

Authors:  R K Zetterman; A Luisada-Opper; C M Leevy
Journal:  Gastroenterology       Date:  1976-03       Impact factor: 22.682
  9 in total
  9 in total

1.  Occurrence and significance of IgG liver membrane autoantibodies (LMA) in chronic liver diseases of different aetiology.

Authors:  R Meliconi; M V Stancari; M Garagnani; M Baraldini; G F Stefanini; F Miglio; G Gasbarrini
Journal:  Clin Exp Immunol       Date:  1983-03       Impact factor: 4.330

2.  Cellular cytotoxicity against autologous hepatocytes in acute and chronic non-A, non-B hepatitis.

Authors:  T Poralla; T H Hütteroth; K H Meyer zum Büschenfelde
Journal:  Gut       Date:  1984-02       Impact factor: 23.059

Review 3.  Immunologic effector mechanisms in hepatitis B-negative chronic active hepatitis.

Authors:  R J Klingenstein; J R Wands
Journal:  Springer Semin Immunopathol       Date:  1980-12

Review 4.  The role of liver membrane antigens as targets in autoimmune type liver disease.

Authors:  K H Meyer zum Büschenfelde; T H Hütteroth; M Manns; B Möller
Journal:  Springer Semin Immunopathol       Date:  1980-12

5.  Lymphocyte transformation test with rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.

Authors:  L Ortona; V Laghi; R Cauda; P Nervo
Journal:  Clin Exp Immunol       Date:  1979-11       Impact factor: 4.330

6.  Antibodies against human liver-specific protein (LSP) in acute and chronic viral hepatitis types A, B and non-A, non-B.

Authors:  R Meliconi; M Baraldini; G F Stefanini; A Facchini; F Miglio; F Bortolotti; A Alberti; G Realdi; P Amoroso
Journal:  Clin Exp Immunol       Date:  1981-11       Impact factor: 4.330

7.  A quantitative ultrastructural analysis of the leukocytes in contact with hepatocytes in chronic active hepatitis, with a cytochemical detection of mononuclear phagocytes.

Authors:  D Bernuau; E Rogier; G Feldmann
Journal:  Am J Pathol       Date:  1982-12       Impact factor: 4.307

8.  Spontaneous cell-mediated (SCMC) and antibody-dependent cellular cytotoxicity (ADCC) in patients with acute and chronic active hepatitis.

Authors:  T H Hütteroth; T Poralla; K H Meyer zum Büschenfelde
Journal:  Klin Wochenschr       Date:  1981-06-15

Review 9.  The immunopathogenesis of chronic HBV induced liver disease.

Authors:  G A Levy; F V Chisari
Journal:  Springer Semin Immunopathol       Date:  1981-04
  9 in total

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