Literature DB >> 55716

Antibody-dependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis.

A M Cochrane, A Moussouros, A D Thomsom, A L Eddleston, R Wiiliams.   

Abstract

Lymphocytes from 12 of 17 patients with chronic active hepatitis were cytotoxic towards isolated hepatocytes in a microcytotoxicity assay. Enriched fractions of B cells, prepared by removal of E-rosetted cells, were cytotoxic in all 12 cases, whereas T-cell fractions, prepared by removal of erythrocyte-antibody-complement-rosetted cells, were cytotoxic in only 1 case (P less than 0-0005). HBsAg positive and negative cases reacted similarly. In 6 patients the addition of 5 mug aggregated IgG significantly reduced cytotoxicity from 54% +/- 15 to 13% +/- 15 (mean +/- 1S.D.) suggesting that K cells may be the effector cell in an antibody-dependent, cell-mediated reaction directed against a liver-specific membrane lipoprotein.

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Year:  1976        PMID： 55716     DOI： 10.1016/s0140-6736(76)91472-0

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  86 in total

1.  Flow cytometric and functional analysis of mononuclear cells infiltrating the liver in experimental autoimmune hepatitis.

Authors:  H Kohda; C Sekiya; M Kanai; Y Yoshida; T Uede; K Kikuchi; M Namiki
Journal:  Clin Exp Immunol       Date:  1990-12       Impact factor: 4.330

Review 2.  Immunological aspects of liver disease.

Authors:  A L Eddleston; P T Donaldson; J E Hegarty; B D Reed
Journal:  Gut       Date:  1991-09       Impact factor: 23.059

Review 3.  Chronic active hepatitis.

Authors:  P J Johnson; I G McFarlane
Journal:  Gut       Date:  1991-09       Impact factor: 23.059

Review 4.  Cellular mechanisms of hepatocyte damage and regulatory mechanisms in autoimmune chronic active hepatitis.

Authors:  S Vento; A L Eddleston
Journal:  Springer Semin Immunopathol       Date:  1990

5.  Alcoholic liver injury.

Authors:  R Williams; M Davis
Journal:  Proc R Soc Med       Date:  1977-05

6.  Lymphocyte populations in liver biopsy specimens from patients with chronic liver disease.

Authors:  J Sanchez-Tapias; H C Thomas; S Sherlock
Journal:  Gut       Date:  1977-06       Impact factor: 23.059

7.  Influence of (+)-cyanidanol-3 on the leukocyte migration inhibition test carried out in the presence of purified protein derivative and hepatitis B surface antigen.

Authors:  J J Vallotton; P C Frei
Journal:  Infect Immun       Date:  1981-05       Impact factor: 3.441

8.  Mechanisms responsible for antibody-dependent, cell-mediated cytotoxicity to isolated hepatocytes in chronic active hepatitis.

Authors:  C Gonzales; A M Cochrane; A L Eddleston; R Williams
Journal:  Gut       Date:  1979-05       Impact factor: 23.059

9.  Autoantibodies against liver-specific membrane lipoprotein in acute and chronic liver diseases: studies on organ-, species-, and disease-specificity.

Authors:  M Manns; K H Meyer zum Büschenfelde; G Hess
Journal:  Gut       Date:  1980-11       Impact factor: 23.059

10.  Hepatocyte damage induced by lymphocytes from patients with chronic liver diseases, as detected by LDH release.

Authors:  E Fernandez-Cruz; P Escartin; A Bootello; M Kreisler; J M Segovia de Arana
Journal:  Clin Exp Immunol       Date:  1978-03       Impact factor: 4.330
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