Literature DB >> 527260

Lymphocyte transformation test with rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.

L Ortona, V Laghi, R Cauda, P Nervo.   

Abstract

Cellular sensitization to rabbit liver specific lipoprotein (RLSP) has been investigated using a lymphocyte transformation test in patients with chronic active hepatitis (CAH). A stimulation index greater than 2 was recorded in twenty out of twenty-five cases (eight of ten HBsAg positive and twelve of fiteen HBsAg negative) while values were lower than 2 in all the normal subjects. These results confirm the finding of sensitization to LSP in chronic active hepatitis irrespective of HBsAg status and show that rabbit LSP can be used as an alternative to the human antigen in the lymphocyte transformation test, and is further evidence that this liver membrane lipoprotein has antigenic determinants which have species-cross-reactivity.

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Year:  1979        PMID： 527260      PMCID： PMC1537866     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  23 in total

1.  In vitro studies on IgG-mediated lymphocyte cytotoxicity in chronic active liver disease.

Authors:  H Kawanishi
Journal:  Gastroenterology       Date:  1977-09       Impact factor: 22.682

Review 2.  Clinical relevance of the liver-specific lipoprotein (lsp).

Authors:  T H Hütteroth; K H Meyer zum Büschenfelde
Journal:  Acta Hepatogastroenterol (Stuttg)       Date:  1978-06

3.  Lymphocytotoxicity test against rabbit hepatocytes in chronic liver diseases.

Authors:  A Facchini; G F Stefanini; M Bernardi; F Miglio; G Gasbarrini; G Labö
Journal:  Gut       Date:  1978-03       Impact factor: 23.059

4.  Inadequate antibody response to hBAg or suppressor T-cell defect in development of active chronic hepatitis.

Authors:  A L Eddleston; R Williams
Journal:  Lancet       Date:  1974-12-28       Impact factor: 79.321

5.  Purification and characterization of human liver-specific membrane lipoprotein (LSP).

Authors:  I G McFarlane; B M Wojcicka; G M Zucker; A L Eddleston; R Williams
Journal:  Clin Exp Immunol       Date:  1977-03       Impact factor: 4.330

6.  Immunological studies in patients with chronic active hepatitis. Cytotoxic activity of lymphocytes to autochthonous liver cells grown in tissue culture.

Authors:  F Paronetto; S Vernace
Journal:  Clin Exp Immunol       Date:  1975-01       Impact factor: 4.330

7.  Hepatocyte damage induced by lymphocytes from patients with chronic liver diseases, as detected by LDH release.

Authors:  E Fernandez-Cruz; P Escartin; A Bootello; M Kreisler; J M Segovia de Arana
Journal:  Clin Exp Immunol       Date:  1978-03       Impact factor: 4.330

8.  Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis.

Authors:  J Miller; M G Smith; C G Mitchell; W D Reed; A L Eddleston; R Williams
Journal:  Lancet       Date:  1972-08-12       Impact factor: 79.321

9.  In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis. Dysfunction of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis.

Authors:  J M Vierling; D L Nelson; W Strober; D M Bundy; E A Jones
Journal:  J Clin Invest       Date:  1977-11       Impact factor: 14.808

10.  Cell-mediated cytotoxicity in chronic active liver disease: a new test system.

Authors:  A J Vogten; N Hadzic; R G Shorter; W H Summerskill; W F Taylor
Journal:  Gastroenterology       Date:  1978-05       Impact factor: 22.682
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  7 in total

1.  Relationship between general or specific immunoreactivity and prognosis in postoperative patients with hepatocellular carcinoma.

Authors:  H Yamasaki; E Okamoto; T Komatsu; Y Manabe; S Shinka
Journal:  Cancer Immunol Immunother       Date:  1990       Impact factor: 6.968

Review 2.  Immunological aspects of chronic active hepatitis.

Authors:  S Vento; A L Eddleston
Journal:  Clin Exp Immunol       Date:  1987-05       Impact factor: 4.330

3.  Study of cellular immunity in experimental autoimmune hepatitis in mice.

Authors:  Y Mori; T Mori; H Yoshida; S Ueda; K Iesato; Y Wakashin; M Wakashin; K Okuda
Journal:  Clin Exp Immunol       Date:  1984-07       Impact factor: 4.330

4.  Study of cellular immunity in experimental autoimmune hepatitis in mice: transfer of spleen cells sensitized with liver proteins.

Authors:  Y Mori; T Mori; S Ueda; H Yoshida; K Iesato; Y Wakashin; M Wakashin; K Okuda
Journal:  Clin Exp Immunol       Date:  1985-09       Impact factor: 4.330

5.  Incidence of antibodies against rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.

Authors:  L Ortona; V Laghi; E Tamburrini; L Troncone; N Bonifazi; P Nervo; R Cauda
Journal:  Clin Exp Immunol       Date:  1983-05       Impact factor: 4.330

6.  Antibodies against human liver-specific protein (LSP) in acute and chronic viral hepatitis types A, B and non-A, non-B.

Authors:  R Meliconi; M Baraldini; G F Stefanini; A Facchini; F Miglio; F Bortolotti; A Alberti; G Realdi; P Amoroso
Journal:  Clin Exp Immunol       Date:  1981-11       Impact factor: 4.330

7.  Histological and immunological investigation of liver-specific protein (LSP) immunized rabbits compared with patients with liver disease.

Authors:  C Feighery; G S McDonald; J F Greally; D G Weir
Journal:  Clin Exp Immunol       Date:  1981-07       Impact factor: 4.330
  7 in total

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