Literature DB >> 6316344

Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.

E Canaani, O Dreazen, A Klar, G Rechavi, D Ram, J B Cohen, D Givol.   

Abstract

The activation of the cellular oncogene c-mos in mouse plasmacytoma XRPC24 was found to result from the insertion of a 4.7-kilobase-pair cellular DNA element, within the c-mos coding region. The element terminates on both sides with a direct repeat of around 335 nucleotides. The repeat as well as internal sequences of the element show strong homology to endogenous intracisternal A-particle (IAP) genes. The IAP genome integrated within c-mos in a head-to-head (5' to 5') configuration. This juxtapositioned the IAP 5' long terminal repeat next to the bulk of the oncogene's coding region and shifted c-mos 5' coding and flanking sequences to a position further upstream. The significance of several aspects of this activation and transposition event is discussed.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6316344      PMCID： PMC390004          DOI： 10.1073/pnas.80.23.7118

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system.

Authors:  P Leder; D Tiemeier; L Enquist
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

2.  Expression of A- and C-type particles in early mouse embryos.

Authors:  D G Chase; L Pikó
Journal:  J Natl Cancer Inst       Date:  1973-12       Impact factor: 13.506

3.  Intracisternal A particles in ova and preimplantation stages of the mouse.

Authors:  P G Calarco; D Szollosi
Journal:  Nat New Biol       Date:  1973-05-16

4.  Retrovirus-like particles containing RNA homologous to the transposable element copia in Drosophila melanogaster.

Authors:  T Shiba; K Saigo
Journal:  Nature       Date:  1983-03-10       Impact factor: 49.962

5.  Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus.

Authors:  E P Reddy; M J Smith; E Canaani; K C Robbins; S R Tronick; S Zain; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

6.  Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element.

Authors:  G Rechavi; D Givol; E Canaani
Journal:  Nature       Date:  1982-12-16       Impact factor: 49.962

7.  Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus.

Authors:  J Papkoff; I M Verma; T Hunter
Journal:  Cell       Date:  1982-06       Impact factor: 41.582

8.  Separation of sarcoma virus-specific and leukemia virus-specific genetic sequences of Moloney sarcoma virus.

Authors:  E M Scolnick; R S Howk; A Anisowicz; P T Peebles; C D Scher; W P Parks
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

9.  Intracisternal A-particle genes: identification in the genome of Mus musculus and comparison of multiple isolates from a mouse gene library.

Authors:  K K Lueders; E L Kuff
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Cloning of integrated Moloney sarcoma proviral DNA sequences in bacteriophage lambda.

Authors:  G F Vande Woude; M Oskarsson; L W Enquist; S Nomura; M Sullivan; P J Fischinger
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205
View more
  63 in total

1.  Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma.

Authors:  C E Malstrom; A L Kotsenas; B Jones
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

2.  cDNA sequence and genomic characterization of intracisternal A-particle-related retroviral elements containing an envelope gene.

Authors:  F U Reuss; H C Schaller
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

3.  Discrete high molecular weight RNA transcribed from the long interspersed repetitive element L1Md.

Authors:  J P Dudley
Journal:  Nucleic Acids Res       Date:  1987-03-25       Impact factor: 16.971

4.  Isolation of genes specifically expressed in flat revertant cells derived from activated ras-transformed NIH 3T3 cells by treatment with azatyrosine.

Authors:  W J Krzyzosiak; N Shindo-Okada; H Teshima; K Nakajima; S Nishimura
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

5.  Co-amplification to tail-to-tail copies of MuRVY and IAPE retroviral genomes on the Mus musculus Y chromosome.

Authors:  J Fennelly; K Harper; S Laval; E Wright; M Plumb
Journal:  Mamm Genome       Date:  1996-01       Impact factor: 2.957

6.  A small nuclear RNA, U5, can transform cells in vitro.

Authors:  K Hamada; T Kumazaki; K Mizuno; K Yokoro
Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272

7.  Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia.

Authors:  K Kongsuwan; J Allen; J M Adams
Journal:  Nucleic Acids Res       Date:  1989-03-11       Impact factor: 16.971

Review 8.  Provirus tagging as an instrument to identify oncogenes and to establish synergism between oncogenes.

Authors:  A Berns
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

9.  Nucleotide sequences of murine intracisternal A-particle gene LTRs have extensive variability within the R region.

Authors:  R J Christy; A R Brown; B B Gourlie; R C Huang
Journal:  Nucleic Acids Res       Date:  1985-01-11       Impact factor: 16.971

10.  Nucleotide sequence of the Syrian hamster intracisternal A-particle gene: close evolutionary relationship of type A particle gene to types B and D oncovirus genes.

Authors:  M Ono; H Toh; T Miyata; T Awaya
Journal:  J Virol       Date:  1985-08       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.