Literature DB >> 2564662

Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia.

K Kongsuwan1, J Allen, J M Adams.   

Abstract

The presence of an altered Hox-2.4 gene in the WEHI3B murine myeloid leukemia suggests that homeobox genes may contribute to neoplasia. A survey of 31 leukemia cell lines of the myeloid, lymphoid and erythroid lineages revealed that Hox-2.4 was expressed only in WEHI3B and the pre-B lymphoid line 70Z/3, in which no DNA rearrangement was observed. To clarify the WEHI3B alteration and normal Hox-2.4 structure, we have sequenced near full length cDNA clones from WEHI3B and 70Z/3, and the 5' portion of the normal Hox-2.4 gene. A WEHI3B cDNA clone demonstrates that an intracisternal A-particle (IAP) provirus has inserted within the first exon of the gene and generated a Hox-2.4 mRNA with a 5' sequence derived from the IAP long terminal repeat. A remarkable degree of similarity found between the amino acid sequences of Hox-2.4 and Hox-3.1, which reside on different chromosomes, supports the notion that an ancient homeobox gene cluster has been duplicated and dispersed early in vertebrate evolution.

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Year:  1989        PMID： 2564662      PMCID： PMC317530          DOI： 10.1093/nar/17.5.1881

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  37 in total

1.  Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.

Authors:  M Imagawa; R Chiu; M Karin
Journal:  Cell       Date:  1987-10-23       Impact factor: 41.582

2.  Primary structure and nuclear localization of a murine homeodomain protein.

Authors:  M Kessel; F Schulze; M Fibi; P Gruss
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

Review 3.  Homeo boxes in the study of development.

Authors:  W J Gehring
Journal:  Science       Date:  1987-06-05       Impact factor: 47.728

4.  Nomenclature for homoeobox-containing genes.

Authors:  G R Martin
Journal:  Nature       Date:  1987 Jan 1-7       Impact factor: 49.962

5.  Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.

Authors:  A Awgulewitsch; M F Utset; C P Hart; W McGinnis; F H Ruddle
Journal:  Nature       Date:  1986 Mar 27-Apr 2       Impact factor: 49.962

6.  Human homoeobox-containing genes in development.

Authors:  D Acampora; M Pannese; M D'Esposito; A Simeone; E Boncinelli
Journal:  Hum Reprod       Date:  1987-07       Impact factor: 6.918

7.  A mouse homeobox containing gene on chromosome 11: sequence and tissue-specific expression.

Authors:  F Meijlink; R de Laaf; P Verrijzer; O Destrée; V Kroezen; J Hilkens; J Deschamps
Journal:  Nucleic Acids Res       Date:  1987-09-11       Impact factor: 16.971

8.  Alternative 5' exons in c-abl mRNA.

Authors:  Y Ben-Neriah; A Bernards; M Paskind; G Q Daley; D Baltimore
Journal:  Cell       Date:  1986-02-28       Impact factor: 41.582

9.  Differential and stage-related expression in embryonic tissues of a new human homoeobox gene.

Authors:  F Mavilio; A Simeone; A Giampaolo; A Faiella; V Zappavigna; D Acampora; G Poiana; G Russo; C Peschle; E Boncinelli
Journal:  Nature       Date:  1986 Dec 18-31       Impact factor: 49.962

10.  A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus.

Authors:  D Duboule; A Baron; P Mähl; B Galliot
Journal:  EMBO J       Date:  1986-08       Impact factor: 11.598
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  35 in total

1.  Identification of regulatory elements within the minimal promoter region of the human endogenous ERV9 proviruses: accurate transcription initiation is controlled by an Inr-like element.

Authors:  G La Mantia; B Majello; A Di Cristofano; M Strazzullo; G Minchiotti; L Lania
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

2.  Identification and characterization of novel human endogenous retroviral sequences prefentially expressed in undifferentiated embryonal carcinoma cells.

Authors:  G La Mantia; D Maglione; G Pengue; A Di Cristofano; A Simeone; L Lanfrancone; L Lania
Journal:  Nucleic Acids Res       Date:  1991-04-11       Impact factor: 16.971

3.  Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

Authors:  C Lavau; S J Szilvassy; R Slany; M L Cleary
Journal:  EMBO J       Date:  1997-07-16       Impact factor: 11.598

4.  Functional heterogeneity of a large family of human LTR-like promoters and enhancers.

Authors:  A Feuchter; D Mager
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

5.  Coordinate regulation of HOX genes in human hematopoietic cells.

Authors:  M C Magli; P Barba; A Celetti; G De Vita; C Cillo; E Boncinelli
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

6.  Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins.

Authors:  C P Chang; Y Jacobs; T Nakamura; N A Jenkins; N G Copeland; M L Cleary
Journal:  Mol Cell Biol       Date:  1997-10       Impact factor: 4.272

7.  Expression of the human endogenous retrovirus HTDV/HERV-K is enhanced by cellular transcription factor YY1.

Authors:  M Knössl; R Löwer; J Löwer
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

8.  AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.

Authors:  W F Shen; J C Montgomery; S Rozenfeld; J J Moskow; H J Lawrence; A M Buchberg; C Largman
Journal:  Mol Cell Biol       Date:  1997-11       Impact factor: 4.272

9.  Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.

Authors:  K Monica; D P LeBrun; D A Dedera; R Brown; M L Cleary
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

10.  Stage-specific expression of intracisternal A-particle sequences in murine myelomonocytic leukemia cell lines and normal myelomonocytic differentiation.

Authors:  Y Takayama; M A O'Mara; K Spilsbury; R Thwaite; P B Rowe; G Symonds
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103
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